New therapeutic options in the management of COPD - focus on roflumilast

被引：22
|
作者：
Antoniu, Sabina Antonela [1 ]
机构：
[1] Univ Med & Pharm, Pulm Dis Univ Hosp, Div Pulm Dis, Iasi, Romania
来源：
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2011年 / 6卷
关键词：
COPD; roflumilast; PDE4; efficacy; safety; OBSTRUCTIVE PULMONARY-DISEASE; PDE4 INHIBITOR ROFLUMILAST; LOW-DOSE THEOPHYLLINE; PHOSPHODIESTERASE ISOZYMES; INFLAMMATION; AIRWAYS; BRONCHODILATORS; NEUTROPHIL; 4D;
D O I：
10.2147/COPD.S7336
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
In chronic obstructive pulmonary disease (COPD) the inflammation occurring in the airways and in other lung tissues is complex and is orchestrated by various mediators including the isoenzyme 4 of the phosphodiesterases family (PDE4), which contributes to bronchoconstriction and inflammation. Various PDE4 inhibitors have been evaluated as potential therapies in asthma or COPD but among these only roflumilast have been authorized in Europe to be used in patients with severe COPD as an add-on to the bronchodilator therapy. This review discusses the existing preclinical and clinical data supporting the use of roflumilast for this therapeutic indication and tackles some of the pending issues related to PDE4 in general and to roflumilast in particular.
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页码：147 / 155
页数：9
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