Requirement of the Fc receptor common γ-chain for γδ T cell-mediated promotion of murine experimental autoimmune encephalomyelitis

被引:14
|
作者
Szalai, AJ
Hu, XZ
Raman, C
Barnum, SR
机构
[1] Univ Alabama, Dept Med, Birmingham, AL 35294 USA
[2] Univ Alabama, Dept Microbiol & Neurol, Birmingham, AL 35294 USA
[3] Univ Alabama, Dept Neurol, Birmingham, AL 35294 USA
关键词
EAE; Fc receptors; gamma delta T cells;
D O I
10.1002/eji.200535285
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunoglobulin Fc gamma receptors (Fc gamma R) are comprised of a ligand-binding alpha-chain that sometimes associates with a cell signaling common gamma-chain. These receptors comprise an important family of effector molecules that link humoral and cell-mediated adaptive immunity and regulate innate immunity. Recent animal studies suggest that Fc gamma R in general, and FcR alpha-chains in particular, are required for full development of experimental autoimmune encephalomyelitis (EAE). We show here that deletion of the gamma-chain renders mice resistant to EAE, whereas deletion of the alpha-chains of Fc gamma RI, Fc gamma RIIB and Fc gamma RIII has no protective effect. Susceptibility to EAE is fully restored in common gamma-chain(-/-) mice into which wild-type splenocytes are adoptively transferred, but EAE is not restored in common gamma-chain(-/-) mice given wild-type splenocytes depleted of 76 T cells. These data indicate that although the common gamma-chain is required for full development of EAE in mice, this requirement is likely Fc gamma R alpha-chain-independent. Expression of the common gamma-chain by gamma delta T cells, probably in conjunction with the T cell receptor/CD3 complex, is likely the key requirement for full development of EAE.
引用
收藏
页码:3487 / 3492
页数:6
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