Azole-resistant invasive aspergillosis in a patient with acute myeloid leukaemia in Germany

被引：0
|
作者：
Hamprecht, A. [1 ]
Buchheidt, D. [2 ]
Vehreschild, J. J. [3 ]
Cornely, O. A. [3 ,4 ]
Spiess, B. [2 ]
Plum, G. [1 ]
Halbsguth, T. V. [3 ]
Kutsch, N. [3 ]
Stippel, D. [5 ]
Kahl, P. [6 ]
Persigehl, T. [7 ]
Steinbach, A. [3 ]
Bos, B. [3 ]
Hallek, M. [3 ]
Vehreschild, M. J. [3 ]
机构：
[1] Univ Cologne, Inst Med Microbiol Immunol & Hyg, D-50931 Cologne, Germany
[2] Heidelberg Univ, Mannheim Univ Hosp, Dept Internal Med Haematol & Oncol 3, D-6800 Mannheim, Germany
[3] Univ Cologne, Dept Internal Med 1, D-50931 Cologne, Germany
[4] Univ Cologne, Clin Trials Ctr Cologne, ZKS Koln BMBF 01KN1106, D-50931 Cologne, Germany
[5] Univ Cologne, Dept Gen Visceral & Canc Surg, D-50931 Cologne, Germany
[6] Univ Hosp Cologne, Inst Pathol, Cologne, Germany
[7] Univ Hosp Cologne, Dept Radiol, Cologne, Germany
来源：
EUROSURVEILLANCE | 2012年 / 17卷 / 36期
关键词：
CYP51A GENE; FUMIGATUS; MUTATIONS; EPIDEMIOLOGY; FREQUENCY; SAMPLES; PCR;
D O I：
暂无
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We report the first culture-proven case of invasive aspergillosis (IA) caused by azole-resistant Aspergillus fumigatus in a patient with acute myeloid leukaemia in Germany. IA presented as breakthrough infection under posaconazole prophylaxis. Analysis of the resistance mechanism revealed the TR/L98H mutation in the cyp51A gene, which indicates an environmental origin of the strain. This case underscores the need for monitoring azole resistance in Aspergillus spp. and for routine susceptibility testing of moulds.
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页码：9 / 11
页数：3
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