The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer

被引：340
|
作者：
Liu, Tao [1 ]
Liu, Pei Y. [1 ]
Marshall, Glenn M. [1 ,2 ]
机构：
[1] Childrens Canc Inst Australia Med Res, Sydney, NSW, Australia
[2] Sydney Childrens Hosp, Ctr Childrens Canc & Blood Disorders, Sydney, NSW, Australia
来源：
CANCER RESEARCH | 2009年 / 69卷 / 05期
基金：
英国医学研究理事会;
关键词：
REGULATES SIRT1; P53; MOUSE;
D O I：
10.1158/0008-5472.CAN-08-3365
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gene expression and deacetylase activity of the class III histone deacetylase SIRT1 are up-regulated in cancer cells due to oncogene overexpression or loss of function of tumor suppressor genes. SIRT1 induces histone deacetylation and methylation, promoter CpG island methylation, transcriptional repression, and deacetylation of tumor suppressor proteins. SIRT1 may play a critical role in tumor initiation, progression, and drug resistance by blocking senescence and apoptosis, and promoting cell growth and angiogenesis. SIRT1 inhibitors have shown promising anticancer effects in animal models of cancer. Further screening for more potent SIRT1 inhibitors may lead to compounds suitable for clinical trials in patients. [Cancer Res 2009;69(5):1702-5]
引用
收藏
页码：1702 / 1705
页数：4
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