Xenogenic demineralized bone matrix: osteoinduction and influence of associated skeletal defects in heterotopic bone formation in rats

被引：18
|
作者：
Torricelli, P [1 ]
Fini, M [1 ]
Rocca, M [1 ]
Giavaresi, G [1 ]
Giardino, R [1 ]
机构：
[1] Ist Ortoped Rizzoli, Serv Chirurg Sperimentale, Dept Expt Surg, I-40136 Bologna, Italy
来源：
INTERNATIONAL ORTHOPAEDICS | 1999年 / 23卷 / 03期
关键词：
Bone Formation; Bone Defect; Femoral Condyle; Bone Matrix; Distant Site;
D O I：
10.1007/s002640050341
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Demineralized bone matrix (DBM) was ectopically: implanted in 36 male Wistar rats. In 18 of the animals a bone defect in the femoral condyles was also created: the left was filled with DBM and the right was left empty as a control. The animals were killed after 2, 4 and 6 weeks and new bone was histologically evaluated, comparing ectopic bone formation with or without distant bone injury. Results showed: (1) osteoinductivity of xenogenic DBM, and (2) earlier mineralization of ectopically implanted DBM in the group with associated skeletal injury. Our results show that xenogenic bone matrix acts as an osteoinductive material and that skeletal injury improves osteogenesis at distant sites.
引用
收藏
页码：178 / 181
页数：4
相关论文
共 50 条
  • [21] Chronic heavy alcohol consumption impairs the ability of demineralized allogenic bone matrix to support osteoinduction in rats
    Iwaniec, U. T.
    Kuah, A.
    Turner, R. T.
    ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, 2023, 47 : 282 - 282
  • [22] OSTEOINDUCTION BY IMPLANTS OF DEMINERALIZED ALLOGENEIC BONE-MATRIX IS DIMINISHED IN VITAMIN-D-DEFICIENT RATS
    VANDERSTEENHOVEN, JJ
    DELUSTRO, FA
    BELL, NH
    TURNER, RT
    CALCIFIED TISSUE INTERNATIONAL, 1988, 42 (01) : 39 - 45
  • [23] Repair of long bone defects with demineralized bone matrix and autogenous bone composite
    Mehmet Taner Ozdemir
    Mustafa Ç. Kir
    Indian Journal of Orthopaedics, 2011, 45 : 226 - 230
  • [24] Repair of long bone defects with demineralized bone matrix and autogenous bone composite
    Ozdemir, Mehmet T.
    Kir, Mustafa C.
    INDIAN JOURNAL OF ORTHOPAEDICS, 2011, 45 (03) : 226 - 230
  • [25] Regenerative Treatment of Peri-Implantitis Bone Defects with a Combination of Autologous Bone and a Demineralized Xenogenic Bone Graft: A Series of 36 Defects
    Wiltfang, Joerg
    Zernial, Oliver
    Behrens, Eleonore
    Schlegel, Andreas
    Warnke, Patrick H.
    Becker, Stephan T.
    CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 2012, 14 (03) : 421 - 427
  • [26] Demineralized homologous bone matrix associated with autogenous bone marrow in the repair of radial segmental bone defects in rabbits
    Filgueiras, RR
    Silva, AM
    Del Carlo, RJ
    Galvao, SR
    Rizzo, D
    BONE, 2005, 36 : S199 - S200
  • [27] Evidence of osteoinduction by grafton demineralized bone matrix in nonhuman primate spinal fusion
    Louis-Ugbo, J
    Murakami, H
    Minamide, A
    Boden, SD
    SPINE, 2004, 29 (04) : 360 - 366
  • [28] Bone Repair of Surgical Defects Filled with Autogenous Bone and Covered with Demineralized Bone Matrix Membrane or Polytetrafluoroethylene Membrane in Rats
    Borrasca, Albanir Gabriel
    Aranega, Alessandra Marcondes
    Magro Filho, Osvaldo
    Timoteo, Carlos Alberto
    INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 2015, 30 (02) : 442 - 449
  • [29] Mechanisms of action of demineralized bone matrix in the repair of cortical bone defects
    Colnot, C
    Romero, DM
    Huang, S
    Helms, JA
    CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2005, (435) : 69 - 78
  • [30] MINERALIZATION AND PH RELATIONSHIPS IN HEALING SKELETAL DEFECTS GRAFTED WITH DEMINERALIZED BONE-MATRIX
    CHAKKALAKAL, DA
    MASHOOF, AA
    NOVAK, J
    STRATES, BS
    MCGUIRE, MH
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1994, 28 (12): : 1439 - 1443
12345