Discovery of adipamides as small molecule NPY Y4 receptor agonists

被引:0
|
作者
Sun, Chongqing [1 ]
Bolton, Scott [1 ]
Huang, Yanting [1 ]
Zhu, Yeheng [1 ]
Mikkilineni, Amarendra [1 ]
Gu, Zhengxiang [1 ]
Murugesan, Natesan [1 ]
Karatholuvhu, Maheswaran [2 ]
Yellapu, Sudhakar [2 ]
Beldona, Dastagiri [2 ]
Dhanusu, Suresh [2 ]
Nayeem, Akbar [1 ]
Krystek, Stanley [1 ]
Li, Yi-Xin [1 ]
Burford, Neil [1 ]
Bertekap, Robert [1 ]
Dickey, Joyce [1 ]
Harden, David [1 ]
Jayachandra, Sukhanya [1 ]
Li, Xin [1 ]
Jefcoat, Steve [1 ]
Zhang, Ge [1 ]
Lehrach, John [1 ]
Schweizer, Liang [1 ]
Zhang, Yuying [1 ]
Fu, Jiyi [1 ]
Cullen, Mary Jane [1 ]
Azzara, Anthony [1 ]
Miller, Keith [1 ]
Pelleymounter, Mary Ann [1 ]
Huang, Christine [1 ]
Lee, Ning [1 ]
Ewing, William R. [1 ]
机构
[1] Bristol Myers Squibb Co, Res & Dev, Princeton, NJ 08543 USA
[2] Syngene Int Ltd, BBRC, Bangalore, Karnataka, India
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
183-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [31] The pharmacology of neuropeptide Y (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes
    Wyss, P
    Stricker-Krongrad, A
    Brunner, L
    Miller, J
    Crossthwaite, A
    Whitebread, S
    Criscione, L
    REGULATORY PEPTIDES, 1998, 75-6 : 363 - 371
  • [32] Efficient Discovery of Selective Small Molecule Agonists of Estrogen-Related Receptor γ using Combinatorial Approach
    Kim, Yongju
    Koh, Minseob
    Kim, Don-Kyu
    Choi, Hueng-Sik
    Park, Seung Bum
    JOURNAL OF COMBINATORIAL CHEMISTRY, 2009, 11 (05): : 928 - 937
  • [33] Small-molecule AT2 receptor agonists
    Hallberg, Mathias
    Sumners, Colin
    Steckelings, U. Muscha
    Hallberg, Anders
    MEDICINAL RESEARCH REVIEWS, 2018, 38 (02) : 602 - 624
  • [34] Discovery and biological evaluation of benzo[a] carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor
    Alper, Phil B.
    Marsilje, Thomas H.
    Mutnick, Daniel
    Lu, Wenshuo
    Chatterjee, Arnab
    Roberts, Michael J.
    He, Yun
    Karanewsky, Donald S.
    Chow, Donald
    Lao, Jianmin
    Gerken, Andrea
    Tuntland, Tove
    Liu, Bo
    Chang, Jonathan
    Gordon, Perry
    Seidel, H. Martin
    Tian, Shin-Shay
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (19) : 5255 - 5258
  • [35] Discovery and characterization of novel small-molecule agonists of G protein-coupled receptor 119
    Zhang, Shu-yong
    Li, Jing
    Xie, Xin
    ACTA PHARMACOLOGICA SINICA, 2014, 35 (04) : 540 - 548
  • [36] Small Molecule Ghrelin Receptor Inverse Agonists and Antagonists
    Cameron, Kimberly O.
    Bhattacharya, Samit K.
    Loomis, Katrina
    JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (21) : 8671 - 8691
  • [37] Internalization of cloned pancreatic polypeptide receptors is accelerated by all types of Y4 agonists
    Parker, MS
    Sah, R
    Sheriff, S
    Balasubramaniam, A
    Parker, SL
    REGULATORY PEPTIDES, 2005, 132 (1-3) : 91 - 101
  • [38] Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells
    Pop, Nathalie
    Igel, Patrick
    Brennauer, Albert
    Cabrele, Chiara
    Bernhardt, Guenther
    Seifert, Roland
    Buschauer, Armin
    JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2011, 31 (04) : 271 - 285
  • [39] Discovery of a small molecule insulin receptor activator
    Salituro, GM
    Pelaez, F
    Zhang, BB
    RECENT PROGRESS IN HORMONE RESEARCH, VOL 56, 2001, 56 : 107 - 126
  • [40] Neuropeptide Y (NPY) family of hormones: Progress in the development of receptor selective agonists and antagonists
    Balasubramaniam, A
    CURRENT PHARMACEUTICAL DESIGN, 2003, 9 (15) : 1165 - 1175