Discovery of adipamides as small molecule NPY Y4 receptor agonists

被引:0
|
作者
Sun, Chongqing [1 ]
Bolton, Scott [1 ]
Huang, Yanting [1 ]
Zhu, Yeheng [1 ]
Mikkilineni, Amarendra [1 ]
Gu, Zhengxiang [1 ]
Murugesan, Natesan [1 ]
Karatholuvhu, Maheswaran [2 ]
Yellapu, Sudhakar [2 ]
Beldona, Dastagiri [2 ]
Dhanusu, Suresh [2 ]
Nayeem, Akbar [1 ]
Krystek, Stanley [1 ]
Li, Yi-Xin [1 ]
Burford, Neil [1 ]
Bertekap, Robert [1 ]
Dickey, Joyce [1 ]
Harden, David [1 ]
Jayachandra, Sukhanya [1 ]
Li, Xin [1 ]
Jefcoat, Steve [1 ]
Zhang, Ge [1 ]
Lehrach, John [1 ]
Schweizer, Liang [1 ]
Zhang, Yuying [1 ]
Fu, Jiyi [1 ]
Cullen, Mary Jane [1 ]
Azzara, Anthony [1 ]
Miller, Keith [1 ]
Pelleymounter, Mary Ann [1 ]
Huang, Christine [1 ]
Lee, Ning [1 ]
Ewing, William R. [1 ]
机构
[1] Bristol Myers Squibb Co, Res & Dev, Princeton, NJ 08543 USA
[2] Syngene Int Ltd, BBRC, Bangalore, Karnataka, India
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
183-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Discovery of Small-Molecule Modulators of the Human Y4 Receptor
    Sliwoski, Gregory
    Schubert, Mario
    Stichel, Jan
    Weaver, David
    Beck-Sickinger, Annette G.
    Meiler, Jens
    PLOS ONE, 2016, 11 (06):
  • [2] Discovery of small molecule agonists targeting neuropeptide Y4 receptor using homology modeling and virtual screening
    Kang, Ning
    Wang, Xiao-Lei
    Zhao, Yaxue
    CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 94 (06) : 2064 - 2072
  • [3] Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36):: Development of an anorectic Y4 receptor selective agonist with picomolar affinity
    Balasubramaniam, A
    Mullins, DE
    Lin, S
    Zhai, W
    Tao, ZY
    Dhawan, VC
    Guzzi, M
    Knittel, JJ
    Slack, K
    Herzog, H
    Parker, EM
    JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (08) : 2661 - 2665
  • [4] Photochromic peptidic NPY Y4 receptor ligands
    Lachmann, D.
    Konieczny, A.
    Keller, M.
    Koenig, B.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2019, 17 (09) : 2467 - 2478
  • [5] Discovery of a New Class of Small Molecule Agonists for the Melanocortin Receptor 4
    Conde-Freiboes, Kilian
    raun, Kirsten
    Ankersen, Michael
    Wulf, Birgitte S.
    OBESITY, 2008, 16 : S188 - S188
  • [6] Y2 and Y4 Receptor Signalling Attenuates the Skeletal Response of Central NPY
    Lee, Nicola J.
    Allison, Susan
    Enriquez, Ronaldo F.
    Sainsbury, Amanda
    Herzog, Herbert
    Baldock, Paul A.
    JOURNAL OF MOLECULAR NEUROSCIENCE, 2011, 43 (02) : 123 - 131
  • [7] Y2 and Y4 Receptor Signalling Attenuates the Skeletal Response of Central NPY
    Nicola J. Lee
    Susan Allison
    Ronaldo F. Enriquez
    Amanda Sainsbury
    Herbert Herzog
    Paul A. Baldock
    Journal of Molecular Neuroscience, 2011, 43 : 123 - 131
  • [8] Hindbrain parabrachial nucleus lesions counteract hyperphagic responses to a NPy y4 receptor agonist
    Baird, John-Paul
    Korboe, Akosua
    Hamuza, Mwanasha
    Ali, Amal
    Grigg, Lindsay
    Lord, Julia
    Swick, Jennifer
    CHEMICAL SENSES, 2015, 40 (07) : 601 - 601
  • [9] Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists
    Mishra, Rama K.
    Shum, Andrew K.
    Platanias, Leonidas C.
    Miller, Richard J.
    Schiltz, Gary E.
    SCIENTIFIC REPORTS, 2016, 6
  • [10] Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists
    Rama K. Mishra
    Andrew K. Shum
    Leonidas C. Platanias
    Richard J. Miller
    Gary E. Schiltz
    Scientific Reports, 6