Current status of ex-vivo liver resection and autologous liver transplantation for end-stage hepatic alveolar echinococcosis

被引:26
|
作者
Yang, Chong [1 ]
Yang, Hong-Ji [1 ]
Deng, Shao-Ping [1 ]
Zhang, Yu [1 ]
机构
[1] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Clin Immunol Translat Med Key Lab Sichuan Prov &, Chengdu 611731, Peoples R China
关键词
Ex-vivo liver resection and autotransplantation (ERAT); hepatic alveolar echinococcosis (HAE); liver transplantation (LT); vascular reconstruction; TERM-FOLLOW-UP; AUTOTRANSPLANTATION; RECONSTRUCTION; SITU; HEPATECTOMY; GRAFTS; REPLACEMENT; EXPERIENCE; INFECTION; PRESSURE;
D O I
10.21037/apm-20-184
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Hepatic alveolar echinococcosis (HAE) is a cosmopolitan zoonosis distribute widely in the northern hemisphere with high estimated 10-year mortality. Radical resection combined with oral albendazole administration are the major methods for HAE treatment, whereas most patients delayed diagnosis and treatment because which was considered as benign disease. For the cases with end-stage HAE could not be treated through conventional hepatectomy, allograft liver transplantation (LT) was regarded as a life-saving technique previously. However, graft shortage, high recurrence rate and long-term immunosuppressive therapy limited its utilization. Since the ex-vivo liver resection and autotransplantation (ERAT) procedure was first used in treating for end-stage HAE in 2011, there are more than 120 HAE cases patients were reported treating in this method up to now. Comparing with LT, ERAT needs neither an organ donor nor long term immunosuppressive therapy, and provide preferable overall survival rates. Based on the conventional ERAT procedure, some modification such as auxiliary partial autologous LT were introduced in the high selected end-stage HAE patients presently. However, the standard procedures for ERAT including surgical details and perioperative management have not been established because of limited reported cases. Also, the present ERAT experience for end-stage HAE treatment are all summarizes by the Chinese surgeon groups. For summarizing the knowledge and experience details, we reviewed present opinions about ERAT for end-stage HAE patients, and presented the future perspectives about this topic in this manuscript. We aimed at discussing the feasibility, indications, preparation, technical details, and postoperative outcomes of ERAT for HAE patients.
引用
收藏
页码:2271 / 2278
页数:8
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