Voxel-based imaging of translocator protein 18kDa (TSPO) in high-resolution PET

被引：9
|
作者：
Ko, Ji Hyun [1 ,2 ]
Koshimori, Yuko [1 ,2 ]
Mizrahi, Romina [1 ]
Rusjan, Pablo [1 ]
Wilson, Alan A. [1 ]
Lang, Anthony E. [2 ,3 ]
Houle, Sylvain [1 ]
Strafella, Antonio P. [1 ,2 ,3 ]
机构：
[1] Univ Toronto, Ctr Addict & Mental Hlth, Res Imaging Ctr, Toronto, ON M5T 2S8, Canada
[2] Univ Toronto, Toronto Western Res Inst, UHN, Div Brain Imaging & Behav Syst Neurosci, Toronto, ON M5T 2S8, Canada
[3] Univ Toronto, Toronto Western Hosp, EJ Safra Program Parkinson Dis, UHN,Movement Disorder Unit, Toronto, ON M5T 2S8, Canada
来源：
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2013年 / 33卷 / 03期
基金：
加拿大健康研究院;
关键词：
inflammation; kinetic modeling; microglia; neurooncology; positron emission tomography; PERIPHERAL BENZODIAZEPINE-RECEPTORS; POSITRON-EMISSION-TOMOGRAPHY; GRAPHICAL ANALYSIS; HUMAN BRAIN; RADIOLIGAND; BINDING; MICROGLIA; TUMORS; LIGAND;
D O I：
10.1038/jcbfm.2012.203
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In vivo imaging of translocator protein 18kDa (TSPO) has received significant attention as potential biomarker of microglia activation. Several radioligands have been designed with improved properties. Our group recently developed an F-18-labeled TSPO ligand, [F-18]-FEPPA, and confirmed its reliability with a 2-tissue compartment model. Here, we extended, in a group of healthy subjects, its suitability for use in voxel-based analysis with the newly proposed graphical analysis approach, Relative-Equilibrium-Gjedde-Patlak (REGP) plot. The REGP plot successfully replicated the total distribution volumes estimated by the 2-tissue compartment model. We also showed its proof-of-concept in a patient with possible meningioma showing increased [F-18]-FEPPA total distribution volume. Journal of Cerebral Blood Flow & Metabolism (2013) 33, 348-350; doi:10.1038/jcbfm.2012.203; published online 2 January 2013
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页码：348 / 350
页数：3
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