Enantioselective synthesis of the C5-C23 segment of biselyngbyaside

被引：13

作者：

Chandrasekhar, Srivari ^{[1
]}

Rajesh, Gontla ^{[1
]}

Naresh, Tumma ^{[1
]}

机构：

[1] CSIR Indian Inst Chem Technol, Div Nat Product Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 03期

关键词：

Biselyngbyaside; Julia-Kocienski olefination; Crimmin's acetate aldol reaction; STEREOSELECTIVE TOTAL-SYNTHESIS; ASYMMETRIC ALDOL ADDITIONS; BLUE-GREEN-ALGAE; ABSOLUTE-CONFIGURATIONS; NATURAL-PRODUCTS; CHEMICAL-SHIFTS; DIHYDROXYLATION; LAULIMALIDE; REAGENTS; FRAGMENT;

D O I：

10.1016/j.tetlet.2012.11.015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereo and enantioselective synthesis of C5-C23 fragment of cytotoxic marine natural product biselyngbyaside is achieved using E-selective methyl lithium addition onto enyne, Crimmin's acetate aldol reaction, Sharpless asymmetric epoxidation, and Julia-Kocienski olefination as the key steps. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：252 / 255

页数：4

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