Magnetic resonance of polyaspartic acid-coated magnetite nanoparticles administered in mice

被引：8
|
作者：
Sadeghiani, N
Barbosa, LS
Guedes, MHA
Chaves, SB
Santos, JG
Silva, O
Pelegrini, F
Azevedo, RB
Morais, PC
Lacava, ZGM
机构：
[1] Univ Brasilia, Inst Ciencias Biol, Dept Genet & Morfol, Inst Biol, BR-70910900 Brasilia, DF, Brazil
[2] Univ Brasilia, Inst Fis Nucl Fis Aplicada, BR-70910970 Brasilia, DF, Brazil
[3] Univ Fed Goias, Inst Fis, BR-74001970 Goiania, Go, Brazil
来源：
IEEE TRANSACTIONS ON MAGNETICS | 2005年 / 41卷 / 10期
关键词：
magnetic fluid (MF); magnetic resonance (MR); nanoparticle biodistribution; polyaspartic acid (PA); LIGHT-MICROSCOPY; FLUID; BIODISTRIBUTION;
D O I：
10.1109/TMAG.2005.855334
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Magnetic resonance (MR) was used in the biodistribution investigation of magnetic nanoparticles (MNPs) surface-coated with polyaspartic acid (PAMF), developed as a biocompatible magnetic fluid (BMF) sample. The data allowed us to obtain the kinetic parameters for MNP disposition from the blood and its uptake by the liver, spleen, and lungs. Light microscopy confirmed the MR results. Genetic and toxicity tests showed that the PAMF is reasonable biocompatible. The PAMF sample presented peculiar biodistribution patterns and may be considered as a potential precursor of anticancer drugs.
引用
收藏
页码：4108 / 4110
页数：3
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