SARS-CoV-2 Virion Stabilization by Zn Binding

被引：13
|
作者：
Morante, Silvia [1 ,2 ]
La Penna, Giovanni [2 ,3 ]
Rossi, Giancarlo [1 ,2 ,4 ,5 ]
Stellato, Francesco [1 ,2 ]
机构：
[1] Univ Roma Tor Vergata, Dipartimento Fis, Rome, Italy
[2] INFN, Sez Roma Tor Vergata, Rome, Italy
[3] CNR, Inst Chem Organometall Cpds, Florence, Italy
[4] Ctr Fermi Museo Stor Fis, Rome, Italy
[5] Ctr Studi & Ric Enrico Fermi, Rome, Italy
来源：
FRONTIERS IN MOLECULAR BIOSCIENCES | 2020年 / 7卷
关键词：
SARS-CoV-2; Zn binding; molecular dynamics computer simulation; zinc finger; tetherin; Bst2; orf7a and orf8 proteins; VIRAL-PROTEINS; ZINC; SIMULATIONS; COMPLEX;
D O I：
10.3389/fmolb.2020.00222
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.
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页数：6
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