SARS-CoV-2 Virion Stabilization by Zn Binding

被引：13

作者：

Morante, Silvia ^{[1
,2
]}

La Penna, Giovanni ^{[2
,3
]}

Rossi, Giancarlo ^{[1
,2
,4
,5
]}

Stellato, Francesco ^{[1
,2
]}

机构：

[1] Univ Roma Tor Vergata, Dipartimento Fis, Rome, Italy

[2] INFN, Sez Roma Tor Vergata, Rome, Italy

[3] CNR, Inst Chem Organometall Cpds, Florence, Italy

[4] Ctr Fermi Museo Stor Fis, Rome, Italy

[5] Ctr Studi & Ric Enrico Fermi, Rome, Italy

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2020年 / 7卷

关键词：

SARS-CoV-2; Zn binding; molecular dynamics computer simulation; zinc finger; tetherin; Bst2; orf7a and orf8 proteins; VIRAL-PROTEINS; ZINC; SIMULATIONS; COMPLEX;

D O I：

10.3389/fmolb.2020.00222

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.

引用

页数：6

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