Lysozyme and DNA binding affinity of Pd(II) and Pt(II) complexes bearing charged N,N-pyridylbenzimidazole bidentate ligands

被引：45

作者：

Mansour, Ahmed M. ^{[1
,2
]}

Shehab, Ola R. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Gamma St, Cairo 12613, Egypt

[2] Julius Maximilians Univ Wurzburg, Inst Anorgan Chem, D-97074 Wurzburg, Germany

来源：

DALTON TRANSACTIONS | 2018年 / 47卷 / 10期

基金：

英国惠康基金;

关键词：

ANTIMICROBIAL ACTIVITY; PLATINUM(II) COMPLEXES; MOLECULAR-STRUCTURES; CRYSTAL-STRUCTURES; RUTHENIUM(II) COMPLEXES; COPPER(II) COMPLEXES; PALLADIUM COMPLEXES; CU(II) COMPLEXES; ACTIVE PD(II); BENZIMIDAZOLE;

D O I：

10.1039/c7dt04347c

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New cisplatin analogue Pd(II) and Pt(II) complexes bearing charged pyridylbenzimidazole derivatives furnished with either an alkylated sulfonate or a phosphonium side chain were synthesized, fully characterized and tested for their antimicrobial and cytotoxic activities against noncancerous human embryonic kidney cells (HEK293). The interactions with CT-DNA were investigated using UV/vis spectroscopy. Assignment of the electronic transitions was performed with the aid of TDDFT. The complexes showed interesting antifungal activity against Candida albicans and Cryptococcus neoformans. The Pd(II) complex conjugated with alkylated triphenylphosphonium exhibited higher cytotoxicity (CC50 = 8.932 mu g mL(-1), equivalent to 12 nM) than the others. The reactivity towards hen egg white lysozyme (HEWL) was investigated by electrospray ionization mass spectrometry. The formation of DNA- and HEWL-adducts was achieved via the noncovalent and covalent interactions.

引用

页码：3459 / 3468

页数：10

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