Secondary structure dependent self-assembly of β-peptides into nanosized fibrils and membranes

被引：99
|
作者：
Martinek, TA
Hetényi, A
Fülöp, L
Mándity, IM
Tóth, GK
Dékány, I
Fülöp, F
机构：
[1] Univ Szeged, Inst Pharmaceut Chem, H-6720 Szeged, Hungary
[2] Univ Szeged, Dept Med Chem, H-6720 Szeged, Hungary
[3] Univ Szeged, Hungarian Acad Sci, Nanostruct Mat Res Grp, H-6720 Szeged, Hungary
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 15期
关键词：
beta-peptides; foldamers; nanomaterials; peptide mimetics; self-assembly;
D O I：
10.1002/anie.200504158
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) In control: The secondary structure dependent self-assembly of β-peptides in solution proves that natural biopolymers are not unique in their highly structured conformational behavior. Stereochemically controlled secondary structural units of β-peptide strands and helices intrinsically self-associate into pleated-sheet sandwiches (see picture) and helix-bundle membranes, respectively. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2396 / 2400
页数：5
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