A novel and efficient synthesis of 3,3-disubstituted indol-2-ones via Passerini three-component reactions in the presence of 4 Å molecular sieves

被引：9
|
作者：
Esmaeili, Abbas Ali [1 ,2 ]
Ghalandarabad, Saeid Amini [1 ]
Jannati, Saeideh [1 ]
机构：
[1] Univ Birjand, Fac Sci, Dept Chem, Birjand, Iran
[2] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad, Iran
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 05期
关键词：
Isatin; Isocyanide; Passerini coupling reaction; Carboxylic acid; 3,3-Disubstituted indol-2-ones; DIALKYL ACETYLENEDICARBOXYLATES; CYANOHYDRIN ESTERS; BENZOYL CYANIDE; ALDEHYDES; ISOCYANIDES; CONVENIENT; CHEMISTRY; ISATINS; KETONES;
D O I：
10.1016/j.tetlet.2012.11.025
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Passerini coupling of cyclohexylisocyanide with isatins and carboxylic acids in the presence of 4 angstrom molecular sieves is described. This process offers a highly efficient and atom-economic access to 3-acyloxy-3-carboxamido-1,3-dihydro-2H-indol-2-ones in high to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：406 / 408
页数：3
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