Antibody therapeutics targeting ion channels: are we there yet?

被引：29

作者：

Sun, Han

Li, Min ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Neurosci, High Throughput Biol Ctr, Baltimore, MD 21205 USA

来源：

ACTA PHARMACOLOGICA SINICA | 2013年 / 34卷 / 02期

基金：

美国国家卫生研究院;

关键词：

ion channel; antibody; autoimmune neurological disorder; channelopathy; protein-based therapeutics; ASPARTATE RECEPTOR MODULATOR; MONOCLONAL-ANTIBODY; CALCIUM-CHANNEL; SODIUM-CHANNELS; POLYCLONAL ANTIBODY; ENDOTHELIAL-CELLS; K+ CHANNELS; CA2+ ENTRY; P-TYPE; SUBUNIT;

D O I：

10.1038/aps.2012.202

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The combination of technological advances, genomic sequences and market success is catalyzing rapid development of antibody-based therapeutics. Cell surface receptors and ion channel proteins are well known drug targets, but the latter has seen less success. The availability of crystal structures, better understanding of gating biophysics and validation of physiological roles now form an excellent foundation to pursue antibody-based therapeutics targeting ion channels to treat a variety of diseases.

引用

页码：199 / 204

页数：6

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