Ti-Catalyzed Synthesis of Exocyclic Allenes on Oxygen Heterocycles

被引：6

作者：

Padial, Natalia M. ^{[1
]}

Hernandez-Cervantes, Carmen ^{[2
]}

Munoz-Bascon, Juan ^{[1
]}

Roldan-Molina, Esther ^{[1
]}

Garcia-Martinez, Mireya ^{[2
]}

Belen Ruiz-Muelle, Ana ^{[2
]}

Rosales, Antonio ^{[3
]}

Alvarez-Corral, Miriam ^{[2
]}

Munoz-Dorado, Manuel ^{[2
]}

Rodriguez-Garcia, Ignacio ^{[2
]}

Enrique Oltra, J. ^{[1
]}

机构：

[1] Univ Granada, Fac Sci, Dept Organ Chem, E-18071 Granada, Spain

[2] Univ Almeria, ceiA3, Organ Chem, Almeria 04120, Spain

[3] Univ Seville, EPS, Dept Chem & Environm Engn, Seville 41011, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 03期

关键词：

Titanium; Oxygen heterocycles; Allenes; Titanocene; Homogeneous catalysis; Cyclization; ENANTIOSELECTIVE SYNTHESIS; CHEMISTRY; TOOL;

D O I：

10.1002/ejoc.201601444

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general method for the straightforward synthesis of exocyclic allenes on five-, six-, seven-, and eight-membered oxygen heterocycles is described. A Barbier-type titanocene(III)-catalyzed cyclization of propargyl halides with a pendant carb-onyl group is the key step of the process. This reaction is compatible with many functional groups, and can be smoothly carried out under neutral and mild conditions at room temperature.

引用

页码：639 / 645

页数：7

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