Ruthenium-Catalyzed Pyrrole Synthesis via Oxidative Annulation of Enamides and Alkynes

被引：142

作者：

Li, Bin ^{[1
]}

Wang, Nuancheng ^{[1
]}

Liang, Yujie ^{[1
]}

Xu, Shansheng ^{[1
]}

Wang, Baiquan ^{[1
,2
]}

机构：

[1] Nankai Univ, State Key Lab Element Organ Chem, Coll Chem, Tianjin 300071, Peoples R China

[2] Chinese Acad Sci, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 01期

关键词：

H BOND ACTIVATION; REGIOSELECTIVE SYNTHESIS; SUBSTITUTED PYRROLES; EFFICIENT SYNTHESIS; CYCLIZATION; AMINES; FUNCTIONALIZATIONS; INDOLES; IMINES; COPPER;

D O I：

10.1021/ol303159h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and regioselective ruthenium-catalyzed oxidative annulation of enamides with alkynes via the cleavage of C(sp(2))-H/N-H bonds is reported. The reactions can afford N-acetyl substituted or N-unsubstituted pyrroles by altering the reaction conditions slightly.

引用

页码：136 / 139

页数：4

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