Interaction of receptor for advanced glycation end products with advanced oxidation protein products induces podocyte injury

被引：22
|
作者：
Yamamoto, Yasuhiko [1 ]
Yamamoto, Hiroshi [1 ]
机构：
[1] Kanazawa Univ, Grad Sch Med Sci, Dept Biochem & Mol Vasc Biol, Kanazawa, Ishikawa 9208640, Japan
来源：
KIDNEY INTERNATIONAL | 2012年 / 82卷 / 07期
关键词：
STRESS; RAGE;
D O I：
10.1038/ki.2012.163
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Chronic kidney disease (CKD) is characterized by progressive decline in renal function. Podocyte dropouts contribute to the pathogenesis of diabetic and nondiabetic CKD. Zhou and colleagues demonstrate that the association between advanced oxidation protein products (AOPPs) and receptor for advanced glycation end products (RAGE) elicited podocyte injuries, using cultured podocytes and mice injected with AOPPs. This study suggests that the blockade of RAGE is preventive and therapeutic against podocyte apoptosis caused by oxidative stress-related AOPPs in CKD. Kidney International (2012) 82, 733-735. doi:10.1038/ki.2012.163
引用
收藏
页码：733 / 735
页数：4
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