Relationship between 17-hydroxyprogesterone caproate concentrations and gestational age at delivery in twin gestation

被引：20

作者：

Caritis, Steve N. ^{[1
]}

Simhan, Hyagriv N. ^{[1
]}

Zhao, Yuan ^{[16
]}

Rouse, Dwight J. ^{[2
,3
]}

Peaceman, Alan M. ^{[4
]}

Sciscione, Anthony ^{[5
]}

Spong, Catherine Y. ^{[17
]}

Varner, Michael W. ^{[6
]}

Malone, Fergal D. ^{[7
]}

Iams, Jay D. ^{[8
]}

Mercer, Brian M. ^{[9
]}

Thorp, John M., Jr. ^{[10
]}

Sorokin, Yoram ^{[11
]}

Carpenter, Marshall ^{[12
]}

Lo, Julie ^{[13
]}

Ramin, Susan M. ^{[14
]}

Harper, Margaret ^{[15
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15260 USA

[2] Univ Alabama Birmingham, Dept Obstet, Med Sch Birmingham, Birmingham, AL USA

[3] Univ Alabama Birmingham, Dept Gynecol, Med Sch Birmingham, Birmingham, AL USA

[4] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[5] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA

[6] Univ Utah, Sch Med, Salt Lake City, UT USA

[7] Columbia Univ, Coll Phys & Surg, New York, NY USA

[8] Ohio State Univ, Ohio State Coll Med, Cleveland, OH USA

[9] Case Western Reserve Univ, Sch Med, Metrohlth Med Ctr, Cleveland, OH USA

[10] Univ N Carolina, Sch Med, Chapel Hill, NC USA

[11] Wayne State Univ, Sch Med, Detroit, MI USA

[12] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA

[13] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

[14] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA

[15] Wake Forest Univ Hlth Sci, Winston Salem, NC USA

[16] George Washington Univ, Ctr Biostat, Washington, DC USA

[17] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2012年 / 207卷 / 05期

关键词：

17-hydroxyprogesterone caproate; pharmacodynamics; twin gestation; 17-ALPHA-HYDROXYPROGESTERONE CAPROATE; PREMATURITY; PREVENTION;

D O I：

10.1016/j.ajog.2012.08.001

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: We sought to evaluate in women with twin gestation the relationship between 17-hydroxyprogesterone caproate (17-OHPC) concentration and gestational age at delivery and select biomarkers of potential pathways of drug action. STUDY DESIGN: Blood was obtained between 24-28 weeks (epoch 1) and 32-35 weeks (epoch 2) in 217 women with twin gestation receiving 17-OHPC or placebo. Gestational age at delivery and concentrations of 17-OHPC, 17-hydroxyprogesterone, progesterone, C-reactive protein (CRP), and corticotrophin-releasing hormone were assessed. RESULTS: Women with higher concentrations of 17-OHPC delivered at earlier gestational ages than women with lower concentrations (P < .001). Women receiving 17-OHPC demonstrated significantly higher (P = .005) concentrations of CRP in epoch 1 than women receiving placebo but CRP values were similar in epoch 2 in both groups. A highly significant (P < .0001) positive relationship was observed between 17-OHPC concentration and progesterone and 17-hydroxyprogesterone concentrations at both epochs. Corticotropin-releasing hormone concentrations did not differ by treatment group. CONCLUSION: 17-OHPC may adversely impact gestational age at delivery in women with twin gestation.

引用

页数：8

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