Structural and functional properties of NAD kinase, a key enzyme in NADP biosynthesis

被引：41
|
作者：
Magni, Giulio [1 ]
Orsomando, Giuseppe [1 ]
Raffaelli, Nadia [1 ]
机构：
[1] Univ Politecn Marche, Ist Biotecnol Biochim, I-60131 Ancona, Italy
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 07期
关键词：
NADP biosynthesis; pyridine dinucleotides; recombinant protein; antimicrobial agents; kinetic analysis;
D O I：
10.2174/138955706777698688
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
NAD kinasc is an essential enzyme, which plays a key role in cellular energy and signal transduction systems. In this report. the recent studies on the features of bacterial and human NAD kinases are summarized. They include detailed kinetic and structural analyses and highlight important differences, which could be exploited for the design of novel selective antimicrobial drugs.
引用
收藏
页码：739 / 746
页数：8
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