Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

被引：75

作者：

Hida, Shigeaki ^{[1
]}

Yamasaki, Sho ^{[2
]}

Sakamoto, Yuzuru ^{[1
]}

Takamoto, Masaya ^{[1
]}

Obata, Kazushige ^{[3
]}

Takai, Toshiyuki ^{[4
]}

Karasuyama, Hajime ^{[3
]}

Sugane, Kazuo ^{[1
]}

Saito, Takashi ^{[2
]}

Taki, Shinsuke ^{[1
]}

机构：

[1] Shinshu Univ, Grad Sch Med, Dept Immunol & Infect Dis, Matsumoto, Nagano 3908621, Japan

[2] RIKEN, Res Ctr Allergy & Immunol, Lab Cell Signaling, Yokohama, Kanagawa 2300045, Japan

[3] Tokyo Med & Dent Univ, Grad Sch, Dept Immune Regulat, Tokyo 1138519, Japan

[4] Tohoku Univ, Dept Expt Immunol, Inst Dev Aging & Canc, Sendai, Miyagi 9808575, Japan

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 02期

基金：

日本学术振兴会;

关键词：

SIGNAL-TRANSDUCTION; TYROSINE KINASE; BETA-CHAIN; T-CELLS; CYTOKINE; SYK; MECHANISM; ITAM; DIFFERENTIATION; MICE;

D O I：

10.1038/ni.1686

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Fc receptor common gamma-chain (FcR gamma) is a widely expressed adaptor bearing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. We show here that basophils lacking FcR gamma developed normally and proliferated efficiently in response to interleukin 3 (IL-3) but were very impaired in IL-3-induced production of IL-4 and in supporting T helper type 2 differentiation. Through its transmembrane portion, FcR gamma associated constitutively with the common beta-chain of the IL-3 receptor and signaled by recruiting the kinase Syk. Retrovirus-mediated complementation demonstrated the essential function of the ITAM of FcR gamma in IL-3 signal transduction. Our results identify a previously unknown mechanism whereby FcR gamma functions to 'route' selective cytokine-triggered signals into the ITAM-mediated IL-4 production pathway.

引用

页码：214 / 222

页数：9

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