Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

被引：75
|
作者：
Hida, Shigeaki [1 ]
Yamasaki, Sho [2 ]
Sakamoto, Yuzuru [1 ]
Takamoto, Masaya [1 ]
Obata, Kazushige [3 ]
Takai, Toshiyuki [4 ]
Karasuyama, Hajime [3 ]
Sugane, Kazuo [1 ]
Saito, Takashi [2 ]
Taki, Shinsuke [1 ]
机构：
[1] Shinshu Univ, Grad Sch Med, Dept Immunol & Infect Dis, Matsumoto, Nagano 3908621, Japan
[2] RIKEN, Res Ctr Allergy & Immunol, Lab Cell Signaling, Yokohama, Kanagawa 2300045, Japan
[3] Tokyo Med & Dent Univ, Grad Sch, Dept Immune Regulat, Tokyo 1138519, Japan
[4] Tohoku Univ, Dept Expt Immunol, Inst Dev Aging & Canc, Sendai, Miyagi 9808575, Japan
来源：
NATURE IMMUNOLOGY | 2009年 / 10卷 / 02期
基金：
日本学术振兴会;
关键词：
SIGNAL-TRANSDUCTION; TYROSINE KINASE; BETA-CHAIN; T-CELLS; CYTOKINE; SYK; MECHANISM; ITAM; DIFFERENTIATION; MICE;
D O I：
10.1038/ni.1686
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Fc receptor common gamma-chain (FcR gamma) is a widely expressed adaptor bearing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. We show here that basophils lacking FcR gamma developed normally and proliferated efficiently in response to interleukin 3 (IL-3) but were very impaired in IL-3-induced production of IL-4 and in supporting T helper type 2 differentiation. Through its transmembrane portion, FcR gamma associated constitutively with the common beta-chain of the IL-3 receptor and signaled by recruiting the kinase Syk. Retrovirus-mediated complementation demonstrated the essential function of the ITAM of FcR gamma in IL-3 signal transduction. Our results identify a previously unknown mechanism whereby FcR gamma functions to 'route' selective cytokine-triggered signals into the ITAM-mediated IL-4 production pathway.
引用
收藏
页码：214 / 222
页数：9
相关论文
共 50 条
  • [1] Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils
    Shigeaki Hida
    Sho Yamasaki
    Yuzuru Sakamoto
    Masaya Takamoto
    Kazushige Obata
    Toshiyuki Takai
    Hajime Karasuyama
    Kazuo Sugane
    Takashi Saito
    Shinsuke Taki
    Nature Immunology, 2009, 10 : 214 - 222
  • [2] Late IL-3-induced phenotypic and functional alterations in human basophils require continuous IL-3 receptor signaling
    Kampfer, Sacha S.
    Odermatt, Andrea
    Dahinden, Clemens A.
    Fux, Michaela
    JOURNAL OF LEUKOCYTE BIOLOGY, 2017, 101 (01) : 227 - 238
  • [3] Heterodimerization of the α and β chains of the interleukin-3 (IL-3) receptor is necessary and sufficient for IL-3-induced mitogenesis
    Orban, PC
    Levings, MK
    Schrader, JW
    BLOOD, 1999, 94 (05) : 1614 - 1622
  • [4] SHIP Represses the Generation of IL-3-Induced M2 Macrophages by Inhibiting IL-4 Production from Basophils
    Kuroda, Etsushi
    Ho, Victor
    Ruschmann, Jens
    Antignano, Frann
    Hamilton, Melisa
    Rauh, Michael J.
    Antov, Andrey
    Flavell, Richard A.
    Sly, Laura M.
    Krystal, Gerald
    JOURNAL OF IMMUNOLOGY, 2009, 183 (06): : 3652 - 3660
  • [5] IL-3 Receptor Expression on Activated Human Th Cells Is Regulated by IL-4, and IL-3 Synergizes with IL-4 to Enhance Th2 Cell Differentiation
    Kumar, Anil
    Rani, Lekha
    Mhaske, Suhas T.
    Pote, Satish T.
    Behera, Shubhanath
    Mishra, Gyan C.
    Wani, Mohan R.
    JOURNAL OF IMMUNOLOGY, 2020, 204 (04): : 819 - 831
  • [6] IL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitro
    Lantz, Chris S.
    Min, Booki
    Tsai, Mindy
    Chatterjea, Devavani
    Dranoff, Glenn
    Galli, Stephen J.
    LABORATORY INVESTIGATION, 2008, 88 (11) : 1134 - 1142
  • [7] Interactions of IL-3 with the IL-3 receptor complex.
    Feng, Y
    Klein, B
    Grabbe, E
    Shieh, JJ
    Hood, W
    McWherter, C
    McKearn, J
    BLOOD, 1997, 90 (10) : 3523 - 3523
  • [8] Protein tyrosine phosphatase activity is required for IL-4 induction of IL-4 receptor α-chain
    Huang, H
    Paul, WE
    JOURNAL OF IMMUNOLOGY, 2000, 164 (03): : 1211 - 1215
  • [9] Shift from IL-3-to IgE-induced IL-4 production as basophils become a predominant source of IL-4
    Yang, Junqi
    Khodoun, Marat
    Orekov, Tatyana
    Mohrs, Katja
    Potter, Crystal
    Mohrs, Markus
    Finkelman, Fred D.
    JOURNAL OF IMMUNOLOGY, 2007, 178
  • [10] REGULATION OF THE IL-3 GENE AND STRUCTURE AND FUNCTION OF THE IL-3 RECEPTOR
    OZU, M
    KOYANONAKAGAWA, N
    NISHIDA, J
    ARAI, N
    MIYAJIMA, A
    ARAI, K
    YOKOTA, T
    ADVANCES IN NEUROIMMUNOLOGY, 1992, 2 (01): : 33 - 53
12345