Synthesis of Novel Hybrid 4H-Pyran-lipoic and 4H-Pyran-azetidine Derivatives

被引：1

作者：

Hernandez-Borja, Fernando ^{[1
]}

Contreras, Leticia ^{[1
]}

Lopez, Julio ^{[1
]}

Alcaraz, Yolanda ^{[2
]}

Cruz, David ^{[1
]}

Estrada-Soto, Samuel ^{[3
]}

Delgado, Francisco ^{[4
]}

Vazquez, Miguel A. ^{[1
]}

机构：

[1] Univ Guanajuato, Dept Quim, Noria Alta S-N, Guanajuato 6050, Gto, Mexico

[2] Univ Guanajuato, Dept Farm, Noria Alta S-N, Guanajuato 36050, Gto, Mexico

[3] Univ Autonoma Estado Morelos, Fac Farm, Ave Univ 1001, Cuernavaca 62209, Morelos, Mexico

[4] Inst Politecn Nacl, Dept Quim Organ, Escuela Nacl Ciencias Biol, Prol Carpio & Plan de Ayala S-N, Mexico City 11340, DF, Mexico

来源：

SYNTHESIS-STUTTGART | 2018年 / 50卷 / 05期

关键词：

molecular hybridization; multicomponent reaction; 4H-pyran-lipoic; 4H-pyran-azetidine core; MOLECULAR HYBRIDIZATION; EX-VIVO; MULTICOMPONENT SYNTHESIS; ANTIBACTERIAL ACTIVITY; VASORELAXANT ACTIVITY; LIPOIC ACID; IN-SILICO; DESIGN; ESTERS; GREEN;

D O I：

10.1055/s-0036-1591730

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, a molecular hybridization strategy was used to design and synthesize two novel series of hybrid compounds: 4H-pyran-lipoic and 4H-pyran-azetidine, employing ammonium hydroxide and involving the participation of aldehydes, malononitrile, and compounds derived from 1-ketoesters to obtain the products with good yields.

引用

页码：1020 / 1026

页数：7

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