Irbesartan attenuates TNF-α-induced ICAM-1, VCAM-1, and E-selectin expression through suppression of NF-κB pathway in HUVECs

被引:1
|
作者
Jiang, Y. [1 ]
Jiang, L. -L. I. [2 ]
Maimaitirexiati, X. -M. Z. Y. [1 ]
Zhang, Y. [1 ]
Wu, L. [1 ]
机构
[1] Xinjiang Med Univ, Tumor Hosp, Intens Care Unit, Urumqi, Peoples R China
[2] Xinjiang Med Univ, Dept Anesthesiol, Tumor Hosp, Urumqi, Peoples R China
关键词
Atherosclerosis; Irbesartan; ICAM-1; VCAM-1; E-selectin; RECEPTOR ANTAGONIST IRBESARTAN; ADHESION MOLECULE EXPRESSION; NECROSIS-FACTOR-ALPHA; ANGIOTENSIN-II; MCP-1; EXPRESSION; HEART-FAILURE; ATHEROSCLEROSIS; ACTIVATION; P38; INHIBITION;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
OBJECTIVE: It is widely recognized that atherosclerosis is a chronic inflammatory disease. Intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and E-selectin play vital roles in inflammatory processes. ICAM-1, VCAM-1, and E-selectin expression is regulated by nuclear factor (NF)-kappa B signaling. It has been reported that irbesartan can decrease expression of atrial fibrillation-Induced atrial adhesion molecule and reduce secretion of inflammation associated cytokines from cultured human carotid atheroma. In this study, we examined whether irbesartan prevents TNF-alpha-induced ICAM-1, VCAM-1, and E-selectin expression in human umbilical vein endothelial cells (HUVECs). MATERIALS AND METHODS: HUVECs were cultured. The expression of ICAM-1, VCAM-1 and MCP-1 was measured by real-time quantitative PCR and ELISA. The expression of NF-kappa B and p-I kappa B-alpha was measured by Western blot. RESULTS: It indicated that in HUVECs irbesartan inhibited expression and secretion of TNF alpha-induced ICAM-1, VCAM-1, and E-selectin. Furthermore, irbesartan inhibited TNF-alpha-induced I kappa B-alpha phosphorylation and NF-kappa B P65 nuclear translocation substantially. In conclusion, irbesartan attenuates TNF alpha-induced ICAM-1, VCAM-1, and E-selectin expression by way of suppressing the NF-kappa B pathways in HUVECs. Irbesartan might postpone the progression of inflammatory diseases, including atherosclerosis. CONCLUSIONS: Irbesartan attenuates TNF alpha-induced ICAM-1, VCAM-1 and MCP-1 expression through the suppression of NF-kappa B pathways. These results suggest irbesartan would be of great benefit to delaying the progression of inflammatory diseases, including atherosclerosis.
引用
收藏
页码:3295 / 3302
页数:8
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