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Irbesartan attenuates TNF-α-induced ICAM-1, VCAM-1, and E-selectin expression through suppression of NF-κB pathway in HUVECs
被引:1
|作者:
Jiang, Y.
[1
]
Jiang, L. -L. I.
[2
]
Maimaitirexiati, X. -M. Z. Y.
[1
]
Zhang, Y.
[1
]
Wu, L.
[1
]
机构:
[1] Xinjiang Med Univ, Tumor Hosp, Intens Care Unit, Urumqi, Peoples R China
[2] Xinjiang Med Univ, Dept Anesthesiol, Tumor Hosp, Urumqi, Peoples R China
关键词:
Atherosclerosis;
Irbesartan;
ICAM-1;
VCAM-1;
E-selectin;
RECEPTOR ANTAGONIST IRBESARTAN;
ADHESION MOLECULE EXPRESSION;
NECROSIS-FACTOR-ALPHA;
ANGIOTENSIN-II;
MCP-1;
EXPRESSION;
HEART-FAILURE;
ATHEROSCLEROSIS;
ACTIVATION;
P38;
INHIBITION;
D O I:
暂无
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
OBJECTIVE: It is widely recognized that atherosclerosis is a chronic inflammatory disease. Intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and E-selectin play vital roles in inflammatory processes. ICAM-1, VCAM-1, and E-selectin expression is regulated by nuclear factor (NF)-kappa B signaling. It has been reported that irbesartan can decrease expression of atrial fibrillation-Induced atrial adhesion molecule and reduce secretion of inflammation associated cytokines from cultured human carotid atheroma. In this study, we examined whether irbesartan prevents TNF-alpha-induced ICAM-1, VCAM-1, and E-selectin expression in human umbilical vein endothelial cells (HUVECs). MATERIALS AND METHODS: HUVECs were cultured. The expression of ICAM-1, VCAM-1 and MCP-1 was measured by real-time quantitative PCR and ELISA. The expression of NF-kappa B and p-I kappa B-alpha was measured by Western blot. RESULTS: It indicated that in HUVECs irbesartan inhibited expression and secretion of TNF alpha-induced ICAM-1, VCAM-1, and E-selectin. Furthermore, irbesartan inhibited TNF-alpha-induced I kappa B-alpha phosphorylation and NF-kappa B P65 nuclear translocation substantially. In conclusion, irbesartan attenuates TNF alpha-induced ICAM-1, VCAM-1, and E-selectin expression by way of suppressing the NF-kappa B pathways in HUVECs. Irbesartan might postpone the progression of inflammatory diseases, including atherosclerosis. CONCLUSIONS: Irbesartan attenuates TNF alpha-induced ICAM-1, VCAM-1 and MCP-1 expression through the suppression of NF-kappa B pathways. These results suggest irbesartan would be of great benefit to delaying the progression of inflammatory diseases, including atherosclerosis.
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页码:3295 / 3302
页数:8
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