Combination of two antibody fragments F(ab′)2/Fab:: An alternative for scorpion envenoming treatment

被引：29
|
作者：
Sami-Merah, Sassia [1 ,2 ]
Hammoudi-Triki, Djelila [1 ,2 ]
Martin-Eauclaire, Marie-France [3 ]
Laraba-Djebari, Fatima [1 ,2 ]
机构：
[1] Fac Biol Sci, Biol Cellulaire & Mol Lab, Algiers 16111, Algeria
[2] Inst Pasteur, Lab Rech & Dev Venins, Algiers, Algeria
[3] Univ Mediterranee, CNRS, Fac Med Nord, IFR Jean Roche,UMR CRN2M 3132, F-13916 Marseille 20, France
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2008年 / 8卷 / 10期
关键词：
scorpion venom; alpha toxins; tissue damage; inflammatory cells; immunotherapy;
D O I：
10.1016/j.intimp.2008.05.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunotherapy is the only effective treatment for scorpion stings. However the efficiency of this treatment varies depending on the forms of the antibodies and route of administration used. The antibodies are mostly injected as F(ab')(2) fragments. In this study, we investigated damage to the heart and lung tissue and the inflammatory response caused by Androctonus australis hector venom, its toxic fraction after molecular filtration or the isolated main alpha toxin (Aah II) in the presence or absence of different antibody molecules. A mixture of antibody fragments, F(ab')(2) and Fab, significantly reduced local leukocytosis, hemorrhage and inflammatory oedema induced by the A. australis hector venom and its toxins. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：1386 / 1394
页数：9
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