Combination of two antibody fragments F(ab′)2/Fab:: An alternative for scorpion envenoming treatment

被引：29

作者：

Sami-Merah, Sassia ^{[1
,2
]}

Hammoudi-Triki, Djelila ^{[1
,2
]}

Martin-Eauclaire, Marie-France ^{[3
]}

Laraba-Djebari, Fatima ^{[1
,2
]}

机构：

[1] Fac Biol Sci, Biol Cellulaire & Mol Lab, Algiers 16111, Algeria

[2] Inst Pasteur, Lab Rech & Dev Venins, Algiers, Algeria

[3] Univ Mediterranee, CNRS, Fac Med Nord, IFR Jean Roche,UMR CRN2M 3132, F-13916 Marseille 20, France

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2008年 / 8卷 / 10期

关键词：

scorpion venom; alpha toxins; tissue damage; inflammatory cells; immunotherapy;

D O I：

10.1016/j.intimp.2008.05.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunotherapy is the only effective treatment for scorpion stings. However the efficiency of this treatment varies depending on the forms of the antibodies and route of administration used. The antibodies are mostly injected as F(ab')(2) fragments. In this study, we investigated damage to the heart and lung tissue and the inflammatory response caused by Androctonus australis hector venom, its toxic fraction after molecular filtration or the isolated main alpha toxin (Aah II) in the presence or absence of different antibody molecules. A mixture of antibody fragments, F(ab')(2) and Fab, significantly reduced local leukocytosis, hemorrhage and inflammatory oedema induced by the A. australis hector venom and its toxins. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：1386 / 1394

页数：9

共 50 条

[1] Purification of antibody Fab and F(ab′)2 fragments using Gradiflow technologyl
Cheung, GLM
Thomas, TM
Rylatt, DB
PROTEIN EXPRESSION AND PURIFICATION, 2003, 32 (01) : 135 - 140
[2] Preparation and characterization of the Fab and F(ab′)2 fragments of an aromatase activity-suppressing monoclonal antibody
Ng, PC
Osawa, Y
STEROIDS, 1997, 62 (12) : 776 - 781
[3] THROMBUS IMAGING WITH FIBRIN-SPECIFIC MONOCLONAL-ANTIBODY AND ITS F(AB')2 AND FAB FRAGMENTS
ROSEBROUGH, SF
GROSSMAN, ZD
KUDRYK, BJ
SUBRAMANIAN, G
MCAFEE, JG
FEDERATION PROCEEDINGS, 1987, 46 (04) : 1130 - 1130
[4] Antitumor effect of monoclonal antibody 3G11 and its F(ab′)2 and Fab′ fragments
Liu, XJ
Liu, XY
Ouyang, ZG
Zhen, YS
ONCOLOGY RESEARCH, 2006, 15 (10-12) : 473 - 474
[5] ADVANTAGES OF COVALENT IMMOBILIZATION OF ANTIBODY FRAGMENTS (FC, FAB, F (AB')2] ON 96 WELL POLYSTYRENE PLATES
GIBBS, J
TITUS, K
ROOT, D
LAWTON, L
FASEB JOURNAL, 1992, 6 (04): : A1222 - A1222
[6] PET of Tumor Angiogenesis with 61/64Cu-Labeled Fab and F(ab')2 Antibody Fragments
Hong, H.
Zhang, Y.
Orbay, H.
Barnhart, T. E.
Cai, W.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2013, 40 : S115 - S115
[7] Two Case Studies of Pregnancy Outcomes after Scorpion Envenomation and F(ab′)2 Scorpion Antivenom Treatment
Mallie, Joanne M.
Hoopmann, Sue
Degan, Janice A.
Boyer, Leslie V.
TOXICON, 2012, 60 (02) : 189 - 189
[8] Evaluation of Fab and F(ab′)2 Fragments and Isotype Variants of a Recombinant Human Monoclonal Antibody against Shiga Toxin 2
Akiyoshi, Donna E.
Sheoran, Abhineet S.
Rich, Curtis M.
Richard, L.
Chapman-Bonofiglio, Susan
Tzipori, Saul
INFECTION AND IMMUNITY, 2010, 78 (03) : 1376 - 1382
[9] IN-VITRO SUPPRESSION OF IMMUNOGLOBULIN ALLOTYPE SYNTHESIS BY FAB AND F(AB')2 FRAGMENTS OF ANTI-ALLOTYPE ANTIBODY
SCHUFFLER, C
DRAY, S
CELLULAR IMMUNOLOGY, 1974, 11 (1-3) : 367 - 376
[10] PREPARATION AND PERFORMANCE OF BISPECIFIC F(AB'-GAMMA)2 ANTIBODY CONTAINING THIOETHER-LINKED FAB'-GAMMA FRAGMENTS
GLENNIE, MJ
MCBRIDE, HM
WORTH, AT
STEVENSON, GT
JOURNAL OF IMMUNOLOGY, 1987, 139 (07): : 2367 - 2375

← 1 2 3 4 5 →