Colony stimulating factor-inducing activity of hesperidin

被引：7

作者：

Kawaguchi, K

Kikuchi, S

Takayanagi, K

Yoshikawa, T

Kumazawa, Y

机构：

[1] Kitasato Univ, Dept Biosci, Sch Sci, Sagamihara, Kanagawa 2288555, Japan

[2] Kitasato Univ, Med Plant Garden, Sch Pharmaceut Sci, Sagamihara, Kanagawa 2288555, Japan

[3] Kitasato Univ, Dept Pharmacognosy, Sch Pharmaceut Sci, Minato Ku, Sagamihara, Kanagawa 2288555, Japan

来源：

PLANTA MEDICA | 1999年 / 65卷 / 04期

关键词：

D O I：

10.1055/s-2006-960788

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

To evaluate immunomodulating activities of bioflavones, colony-stimulating factor (CSF)-inducing activity of two dihydroflavones, three flavones and three flavonols were tested. These samples were suspended in saline and injected intraperitoneally (i.p.) into mice at a dose of 1 mg 6h before bleeding. All compounds carrying the glucosyl-rhamnose moiety showed potent activity. Among them, hesperidin exhibited the strongest activity. Serum CSF production in mice injected with 1 mg hesperidin reached a peak at 9 h later. The activity of hesperidin was dose-dependent at a range of 0.3 to 20 mg/mouse.

引用

页码：365 / 366

页数：2

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