A new method for studying the interaction between chlorpromazine and phospholipid bilayer

被引：16

作者：

Zhang, Lixue ^{[1
]}

Liu, Jiyang ^{[1
]}

Wang, Erkang ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Grad Sch, Beijing 100039, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 373卷 / 02期

基金：

中国国家自然科学基金;

关键词：

chlorpromazine; phospholipid bilayer; interaction; gold nanoparticles; probes;

D O I：

10.1016/j.bbrc.2008.05.187

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The spectroscopic and transmission electron microscopy (TEM) studies of interaction between chlorpromazine (CPZ) and dimyristoyl phosphatidylglycerol (DMPG) bilayer by using gold nanoparticles (AuN-Ps) as probes are reported. The DMPG bilayer-protected AuNPs were prepared by a simple one-step method. The DMPG bilayer tethered on the AuNPs was considered as a biomembrane model. The addition of CPZ affected the surface plasmon resonance (SPR) and morphology of the prepared AuNPs, and this effect was monitored by UV-vis spectroscopy and TEM. The interaction between CPZ and DMPG bialyer was CPZ concentration-dependent, and the possible mechanism was discussed. This simple and facile method may be quite general and work for other surface active drug-biomembrane or protein-biomembrane interactions. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：202 / 205

页数：4

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