Porphyromonas gingivalis-specific immunoglobulin G prevents P-gingivalis-elicited oral bone loss in a murine model

被引：23
|
作者：
Gibson, FC
Gonzalez, DA
Wong, J
Genco, CA
机构：
[1] Boston Univ, Med Ctr, Dept Med, Infect Dis Sect, Boston, MA 02118 USA
[2] Boston Univ, Med Ctr, Goldman Sch Dent Med, Dept Oral Biol & Periodontol, Boston, MA 02118 USA
来源：
INFECTION AND IMMUNITY | 2004年 / 72卷 / 04期
关键词：
D O I：
10.1128/IAI.72.4.2408-2411.2004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Active immunization with Porphyromonas gingivalis whole-cell preparations has been shown to prevent P. gingivalis infection and oral bone loss. Employing passive antibody transfer and opsonization, we demonstrate with this study that immunization-elicited P. gingivalis-specific immunoglobulin G facilitates clearance of P. gingivalis in a subcutaneous chamber model and prevents P. gingivalis-elicited oral bone loss.
引用
收藏
页码：2408 / 2411
页数：4
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