Tracking immune cells in vivo using magnetic resonance imaging

被引：372
|
作者：
Ahrens, Eric T. [1 ]
Bulte, Jeff W. M. [2 ,3 ]
机构：
[1] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA
[2] Johns Hopkins Univ, Dept Biomed Engn, Dept Radiol & Radiol Sci,Div MR Res,Dept Oncol, Dept Chem & Biomol Engn,Inst Cell Engn,Sch Med, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Cellular Imaging Sect & Vasc Biol Program, Baltimore, MD 21205 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 10期
基金：
美国国家卫生研究院;
关键词：
SUPERPARAMAGNETIC IRON-OXIDE; INFLAMMATORY-BOWEL-DISEASE; NEURAL STEM-CELLS; DENDRITIC CELLS; T-CELLS; NONINVASIVE DETECTION; CONTRAST AGENTS; MULTIPLE-SCLEROSIS; GENE-EXPRESSION; F-19; MRI;
D O I：
10.1038/nri3531
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The increasing complexity of in vivo imaging technologies, coupled with the development of cell therapies, has fuelled a revolution in immune cell tracking in vivo. Powerful magnetic resonance imaging (MRI) methods are now being developed that use iron oxide- and F-19-based probes. These MRI technologies can be used for image-guided immune cell delivery and for the visualization of immune cell homing and engraftment, inflammation, cell physiology and gene expression. MRI-based cell tracking is now also being applied to evaluate therapeutics that modulate endogenous immune cell recruitment and to monitor emerging cellular immunotherapies. These recent uses show that MRI has the potential to be developed in many applications to follow the fate of immune cells in vivo.
引用
收藏
页码：755 / 763
页数：9
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