Synthesis, Crystal Structure and Biological activity of N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide

被引：0
|
作者：
Tong, Jian-Ying [1 ]
Sun, Na-Bo [1 ]
Wu, Hong-Ke [2 ]
Liu, Xing-Hai [2 ]
机构：
[1] Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou 310015, Zhejiang, Peoples R China
[2] Zhejiang Univ Technol, Coll Chem Engn & Mat Sci, Hangzhou 310014, Zhejiang, Peoples R China
来源：
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2013年 / 35卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Crystal structure; synthesis; 1,3,4-thiadiazole; herbicidal activity; fungicidal activity; METAL-COMPLEXES; DERIVATIVES; MOIETY;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new 1, 3, 4-thiadiazole compound, N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl) cyclopropanecarboxamide, was synthesized and its structure was confirmed by H-1 NMR, MS and HRMS. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test showed that the synthesized compound has moderate herbicidal activity against Brassica campestris and fungicidal activities against Sclerotinia sclerotiorum(Lib.) de Bary, Rhizoctonia solanii, Fusarium oxysporum, Corynespora cassiicola, and Botrytis cinerea.
引用
下载
收藏
页码：1349 / 1353
页数：5
相关论文
共 50 条
  • [1] Synthesis, Crystal Structure and Bioactivity of N-(5-propyl-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide
    Sun, Na-Bo
    Jin, Jian-Zhong
    Lei, Chao
    He, Fang-Yue
    ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (14) : 7820 - 7822
  • [2] Synthesis, Crystal Structure and Biological Activity of N-[5-(E)-Styryl-1,3,4-thiadiazol-2-yl]-N′-arylureas
    Song, Xinjian
    Wang, Fasong
    Li, Shirong
    Hu, Weibing
    Wang, Yangang
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2011, 31 (04) : 572 - 576
  • [3] Synthesis, structure and biological activity of N-[5-(4-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl]-N′-aroylureas
    Song, Xin-Jian
    Wang, Sheng
    Tan, Xiao-Hong
    Wang, Zi-Yun
    Wang, Yan-Gang
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2007, 27 (01) : 72 - 76
  • [4] Synthesis, crystal structure and biological activity of N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)-N′-aroylureas
    Song, Xin-Jian
    Tan, Xiao-Hong
    Yu, Ai-Nong
    Wang, Yan-Gang
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2006, 26 (06) : 803 - 807
  • [5] Synthesis and biological activity of N-[5-(pyrid-4-yl)-1,3,4-thiadiazol-2-yl]-N′-aroylureas
    Song, XJ
    Feng, GR
    Chen, CB
    Zhang, ZW
    Wang, YG
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2005, 25 (12) : 1587 - 1590
  • [6] Synthesis, Crystal Structure and Antitumor Activity of N-[5-(Benzylthio)-1,3,4-thiadiazol-2-yl]-4-chlorobenzamide
    马小平
    黄钰天
    宋新建
    王艳
    王军刚
    李耀华
    Chinese Journal of Structural Chemistry, 2017, 36 (08) : 1321 - 1326
  • [7] Synthesis, Crystal Structure and Antitumor Activity of N-[5-(Benzylthio)-1,3,4-thiadiazol-2-yl]-4-chlorobenzamide
    Ma Xiao-Ping
    Hang Yu-Tian
    Song Xin-Jian
    Wang Yan
    Wang Jun-Gang
    Li Yao-Hua
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2017, 36 (08) : 1321 - 1326
  • [8] Synthesis and Biological Activity of [5-(Arylmethylideneamino)-1,3,4-thiadiazol-2-yl]thioacetanilides
    Wei, Tai-Bao
    Wang, Wen-Li
    Guo, Xiao-Di
    Xu, Rong
    Zhang, You-Ming
    Da, Wen-Yan
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2008, 28 (10) : 1820 - 1825
  • [9] Synthesis and acaricidal activity of N-(1,3,4-thiadiazol-2-yl)pyrazole-5-carboxamides and N-(1,3,4-thiadiazol-2-yl)thiazole-5-carboxamides
    Shiga, Y
    Okada, I
    Fukuchi, T
    JOURNAL OF PESTICIDE SCIENCE, 2003, 28 (03): : 310 - 312
  • [10] Synthesis, Crystal Structure and Biological Activity of N-(2,6-Difluorobenzoyl)-N′-[5-(4-trifluoromethyl-phenyl)-1,3,4-thiadiazol-2-yl]ure
    Shao Yu
    Yang Ping
    Li Shi-Rong
    Wang Fa-Song
    Hu Wei-Bing
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2011, 30 (06) : 848 - 852
12345