Synthesis, NMR spectral studies and antimicrobial evaluation of some 2-(benzothiazol-2-yl)-1-(alkyl-2r,6c-diarylpiperidin-4-ylidine)hydrazine derivatives

被引：0

作者：

Xavier, J. John Francis ^{[1
]}

Venkateswaramoorthi, R. ^{[1
]}

Kamaraj, A. ^{[1
]}

Krishnasamy, K. ^{[1
]}

机构：

[1] Annamalai Univ, Dept Chem, Annamalainagar 608002, Tamilnadu, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 11期

关键词：

2r; 6c-Diarylpiperidin-4-one; 2-Mercaptobenzothiazole; Hydrazine hydrate; NMR techniques; Antibacterial activity; Antifungal activity; BIOLOGICAL-ACTIVITY; PMR;

D O I：

10.1007/s00044-013-0533-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Substituted 2-(benzothiazol-2-yl)-1-(alkyl-2,6-diarylpiperidin-4-ylidine)hydrazines 10-17 were synthesized by the condensation of different 2r,6c-diarylpiperidin-4-ones 1-8 with 2-hydrazinobenzothiazole 9. All the synthesized compounds were investigated in solution and in the solid state by IR, H-1, C-13 and 2D NMR spectral techniques. The structure-activity relationships were studied by the screening of the antimicrobial activity over a representative panel of bacterial and fungal strains using two-fold serial dilution method.

引用

页码：5105 / 5111

页数：7

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