A practical synthesis of (-)fosfomycin from its enantiomer

被引：2
|
作者：
Zhang, Meng [1 ]
Yu, Zheng [1 ]
Li, Ji Jun [1 ]
Yin, Da Li [2 ]
机构：
[1] Beijing Collab Pharma Co Ltd, Beijing 102600, Peoples R China
[2] Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2008年 / 19卷 / 11期
关键词：
Fosfomycin; Enantiomer; Phosphonate;
D O I：
10.1016/j.cclet.2008.07.020
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(+)-cis-(1S, 2R)-Epoxypropylphosphonic acid, the enantiomer of fosfomycin, which is the industrial side-product in the preparation of the antibiotic fosfomycin, was converted into (-)fosfomycin by a seven-step procedure. The esterification of the dihydroxyphosphonic intermediate was the key step. The title compound was obtained in good yield and its optical purity was up to the medicine quality standard of Chinese Pharmacopoeia. (C) 2008 Meng Zhang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：1297 / 1300
页数：4
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