Optical Control of a Biological Reaction-Diffusion System

被引：21

作者：

Glock, Philipp ^{[1
]}

Broichhagen, Johannes ^{[2
,3
]}

Kretschmer, Simon ^{[1
]}

Blumhardt, Philipp ^{[1
]}

Muecksch, Jonas ^{[1
]}

Trauner, Dirk ^{[2
,4
]}

Schwille, Petra ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Cellular & Mol Biophys, Klopferspitz 18, D-82152 Martinsried, Germany

[2] Ludwig Maximilians Univ Munchen, Dept Chem, Butenandtstr 5-13, D-81377 Munich, Germany

[3] Max Planck Inst Med Res, Dept Chem Biol, Jahnstr 29, D-69120 Heidelberg, Germany

[4] NYU, Dept Chem, Silver Ctr Arts & Sci, 100 Washington Sq East, New York, NY 10003 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 09期

关键词：

chemical oscillators; optical control; photoswitches; pattern formation; synthetic biology; CELL-DIVISION; ESCHERICHIA-COLI; PATTERN-FORMATION; CHEMICAL-SYSTEM; MINE; PROTEINS; FEEDBACK; PEPTIDE; WAVES;

D O I：

10.1002/anie.201712002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Patterns formed by reaction and diffusion are the foundation for many phenomena in biology. However, the experimental study of reaction-diffusion (R-D) systems has so far been dominated by chemical oscillators, for which many tools are available. In this work, we developed a photoswitch for the Min system of Escherichia coli, a versatile biological in vitro R-D system consisting of the antagonistic proteins MinD and MinE. A MinE-derived peptide of 19 amino acids was covalently modified with a photoisomerizable crosslinker based on azobenzene to externally control peptide-mediated depletion of MinD from the membrane. In addition to providing an on-off switch for pattern formation, we achieve frequency-locked resonance with a precise 2D spatial memory, thus allowing new insights into Min protein action on the membrane. Taken together, we provide a tool to study phenomena in pattern formation using biological agents.

引用

页码：2362 / 2366

页数：5

共 50 条

[1] On the Regional Control of a Reaction-Diffusion System SIR
El Alami Laaroussi, Adil
Rachik, Mostafa
[J]. BULLETIN OF MATHEMATICAL BIOLOGY, 2019, 82 (01)
[2] Signal Transmission of Biological Reaction-Diffusion System by Using Synchronization
Zhou, Lingli
Shen, Jianwei
[J]. FRONTIERS IN COMPUTATIONAL NEUROSCIENCE, 2017, 11
[3] Solvability for a reaction-diffusion system modeling biological transportation network
Li, Bin
Wang, Zhi
[J]. Zeitschrift fur Angewandte Mathematik und Physik, 2024, 75 (06):
[4] Optimal control strategies for a reaction-diffusion epidemic system
Zhou, Min
Xiang, Huili
Li, Zuxiong
[J]. NONLINEAR ANALYSIS-REAL WORLD APPLICATIONS, 2019, 46 : 446 - 464
[5] STABILIZING A REACTION-DIFFUSION SYSTEM VIA FEEDBACK CONTROL
Dodea, Smaranda C.
[J]. ANALELE STIINTIFICE ALE UNIVERSITATII AL I CUZA DIN IASI-SERIE NOUA-MATEMATICA, 2013, 59 (01): : 191 - 200
[6] On the dynamics of a reaction-diffusion system
Adomian, G
[J]. APPLIED MATHEMATICS AND COMPUTATION, 1997, 81 (01) : 93 - 95
[7] AN INTEGRAL FOR A REACTION-DIFFUSION SYSTEM
BRITTON, NF
[J]. APPLIED MATHEMATICS LETTERS, 1991, 4 (01) : 43 - 47
[8] On the dynamics of a reaction-diffusion system
[J]. Appl Math Comput (New York), 1 (93):
[9] SOLITONS IN A REACTION-DIFFUSION SYSTEM
TUCKWELL, HC
[J]. SCIENCE, 1979, 205 (4405) : 493 - 495
[10] Control of spatiotemporal chaos: a study with an autocatalytic reaction-diffusion system
Natl Chemical Lab, Pune, India
[J]. Pramana J Phys, 1 pt 1 (303-323):

← 1 2 3 4 5 →