Synthesis and application of bimetallic chiral [Co(salen)]-type complexes:: a new catalytic approach to synthesis of optically pure β-blockers via kinetic resolution of epichlorohydrin

被引：24
|
作者：
Kawthekar, Rahul B. [1 ]
Bi, Wen-tao [1 ]
Kim, Geon-Joong [1 ]
机构：
[1] Inha Univ, Dept Chem Engn, Inchon 402751, South Korea
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2008年 / 22卷 / 10期
关键词：
kinetic resolution; beta-blockers; asymmetric catalysis; cobalt salen; alpha-aryloxy alcohols; ionic liquids; nonlinear effect;
D O I：
10.1002/aoc.1447
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A series of bimetallic chiral [Co(salen)]-type complexes were successfully applied for the synthesis of optically pure beta-blockers via phenolic kinetic resolution (PKR) of racemic epichlorohydrin [2-(chloromethyl)oxirane; (+/-)ECH]. The reaction proceeded readily at room temperature and consequently provided enantiomerically enriched corresponding alpha-aryloxy alcohols with excellent enantioselectivities of up to 98% ee. The PKR method described in this work is highly efficient and straightforward strategy for the synthesis of chiral building blocks. Copyright (C) 2008 John Wiley & Sons, Ltd.
引用
收藏
页码：583 / 591
页数：9
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