Cancer - DNA damage enables p73

被引：66
|
作者：
White, E
Prives, C
机构：
[1] Canc Inst New Jersey, Dept Mol Biol & Biochem, Ctr Adv Biotechnol & Med, Howard Hughes Med Inst, Piscataway, NJ 08854 USA
[2] Rutgers State Univ, Piscataway, NJ 08854 USA
[3] Columbia Univ, Dept Biol Sci, Sherman Fairchild Ctr Life Sci, New York, NY 10027 USA
来源：
NATURE | 1999年 / 399卷 / 6738期
关键词：
D O I：
10.1038/21539
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The'guardian of the genome', p53, is the best-known tumour-suppressor gene. Two other proteins — p63 and p73 — have similar sequences and properties to p53. But p53 is the only one to be induced by DNA damage. Or at least it was. A new study shows that, in fact, p73 is also induced by DNA damage via the non-receptor tyrosine kinase c-Abl.
引用
收藏
页码：734 / +
页数：3
相关论文
共 50 条
  • [31] p73基因
    黄君富
    房殿春
    鲁容
    生命的化学, 1998, (03) : 9 - 10
  • [32] DNp63 transcription is regulated by p53 and p73 upon DNA damage in keratinocytes
    Papoutsaki, M
    Lanza, M
    Marinari, B
    Chimenti, S
    Costanzo, A
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (02)
  • [33] p73 in apoptosis
    Stiewe, T
    Pützer, BM
    APOPTOSIS, 2001, 6 (06) : 447 - 452
  • [34] p73 in apoptosis
    T. Stiewe
    B. M. Pützer
    Apoptosis, 2001, 6 : 447 - 452
  • [35] The impact of p53 and p73 on aneuploidy and cancer
    Tomasini, Richard
    Mak, Tak W.
    Melino, Gerry
    TRENDS IN CELL BIOLOGY, 2008, 18 (05) : 244 - 252
  • [36] p73β is regulated by protein kinase Cδ catalytic fragment generated in the apoptotic response to DNA damage
    Ren, J
    Datta, R
    Shioya, H
    Li, YQ
    Oki, EJ
    Biedermann, V
    Bharti, A
    Kufe, D
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (37) : 33758 - 33765
  • [37] Erratum: p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
    Zhi-Min Yuan
    Hisashi Shioya
    Takatoshi Ishiko
    Xiangao Sun
    Jijie Gu
    YinYin Huang
    Hua Lu
    Surender Kharbanda
    Ralph Weichselbaum
    Donald Kufe
    Nature, 1999, 400 : 792 - 792
  • [38] DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes
    Costanzo, A
    Merlo, P
    Pediconi, N
    Fulco, M
    Sartorelli, V
    Cole, PA
    Fontemaggi, G
    Fanciulli, M
    Schiltz, L
    Blandino, G
    Balsano, C
    Levrero, M
    MOLECULAR CELL, 2002, 9 (01) : 175 - 186
  • [39] Mechanisms of Functional Pleiotropy of p73 in Cancer and Beyond
    Logotheti, Stella
    Richter, Christin
    Murr, Nico
    Spitschak, Alf
    Marquardt, Stephan
    Puetzer, Brigitte M.
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [40] Activation of p73 silent allele in lung cancer
    Mai, M
    Yokomizo, A
    Qian, CP
    Yang, P
    Tindall, DJ
    Smith, DI
    Liu, WG
    CANCER RESEARCH, 1998, 58 (11) : 2347 - 2349
12345