Salviae radix root extract inhibits immunoglobulin E-mediated allergic reaction

被引：14
|
作者：
Kim, HM [1 ]
Lee, EH
Lee, JH
Jung, JA
Kim, JJ
机构：
[1] Wonkwang Univ, Dept Oriental Pharm, Coll Pharm, Iksan 570749, Chonbuk, South Korea
[2] Kwangyang Coll, Dept Dent Hyg, Kwangyang 545800, Chonnam, South Korea
[3] Wonkwang Univ, Sch Med, Dept Anat, Iksan 570749, Chonbuk, South Korea
来源：
GENERAL PHARMACOLOGY | 1999年 / 32卷 / 05期
关键词：
Salviae radix; immediate allergic reaction; anti-dinitrophenyl IgE; histamine; compound; 48/80; cAMP;
D O I：
10.1016/S0306-3623(98)00226-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the effects of the aqueous extract of Salviae radix root (SRRAE) on immediate allergic reactions. SRRAE inhibited by 72.7% passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) immunoglobulin E (IgE). SRRAE dose dependently inhibited histamine release and tumor necrosis factor-alpha production from the rat peritoneal mast cells (RPMCs) by anti-DNP IgE. However, SRRAE showed no significant inhibitory effect on compound 48/80-induced systemic allergic reaction and histamine release from RPMCs. The level of cAMP in RPMCs, when SRRAE was added, significantly increased compared with that of a normal control. These results indicate that SRRAE may contain compounds with actions that inhibit anti-DNP IgE-induced mast cell degranulation in rats. (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：603 / 608
页数：6
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