Repeated treatment with SA4503, a selective sigma1 receptor agonist, up-regulates α1-adrenergic system.: A behavioral study

被引：0

作者：

Skuza, G ^{[1
]}

Kolasiewicz, W ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Pharmacol, Dept Pharmacol, PL-31343 Krakow, Poland

来源：

POLISH JOURNAL OF PHARMACOLOGY | 2001年 / 53卷 / 05期

关键词：

sigma; agonist; repeated treatment; phenylephrine; clonidine; behavioral models;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The obtained results indicate that SA4503, a selective sigma(1) receptor agonist, given repeatedly (but not acutely) enhanced the effects of phenylephrine, alpha (1)-adrenoceptor agonist, and clonidine (stimulating the postsynaptic alpha (1)-adrenoceptors at high dose) in behavioral models (hyperexploratory activity in rats and aggressiveness in mice, respectively).

引用

页码：547 / 550

页数：4

共 32 条

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[32] EFFECTS OF CHRONIC SCH23390 TREATMENT ON THE BIOCHEMICAL AND BEHAVIORAL PROPERTIES OF D1 AND D2 DOPAMINE-RECEPTORS - POTENTIATED BEHAVIORAL-RESPONSES TO A D2 DOPAMINE AGONIST AFTER SELECTIVE D1 DOPAMINE RECEPTOR UP-REGULATION
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