Repeated treatment with SA4503, a selective sigma1 receptor agonist, up-regulates α1-adrenergic system.: A behavioral study

被引：0
|
作者：
Skuza, G [1 ]
Kolasiewicz, W [1 ]
机构：
[1] Polish Acad Sci, Inst Pharmacol, Dept Pharmacol, PL-31343 Krakow, Poland
来源：
POLISH JOURNAL OF PHARMACOLOGY | 2001年 / 53卷 / 05期
关键词：
sigma; agonist; repeated treatment; phenylephrine; clonidine; behavioral models;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The obtained results indicate that SA4503, a selective sigma(1) receptor agonist, given repeatedly (but not acutely) enhanced the effects of phenylephrine, alpha (1)-adrenoceptor agonist, and clonidine (stimulating the postsynaptic alpha (1)-adrenoceptors at high dose) in behavioral models (hyperexploratory activity in rats and aggressiveness in mice, respectively).
引用
收藏
页码：547 / 550
页数：4
相关论文
共 32 条
  • [1] Cardioprotective Effect of the Selective Sigma-1 Receptor Agonist, SA4503
    Hirano, Kohga
    Tagashira, Hideaki
    Fukunaga, Kohji
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2014, 134 (06): : 707 - 713
  • [2] Binding properties of SA4503, a novel and selective sigma(1) receptor agonist
    Matsuno, K
    Nakazawa, M
    Okamoto, K
    Kawashima, Y
    Mita, S
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 306 (1-3) : 271 - 279
  • [3] Chronic treatment with a selective ligand for the sigma-1 receptor chaperone, SA4503, up-regulates BDNF protein levels in the rat hippocampus
    Kikuchi-Utsumi, Kazue
    Nakaki, Toshio
    NEUROSCIENCE LETTERS, 2008, 440 (01) : 19 - 22
  • [4] A potential antidepressant activity of SA4503, a selective σ1 receptor agonist
    Skuza, G
    Rogóz, Z
    BEHAVIOURAL PHARMACOLOGY, 2002, 13 (07): : 537 - 543
  • [5] Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats:: An in vivo electrophysiological study
    Minabe, Y
    Matsuno, K
    Ashby, CR
    SYNAPSE, 1999, 33 (02) : 129 - 140
  • [6] Effects of SA4503, a novel sigma1 receptor agonist, on monoamine metabolism in the brain of mice exposed to tail-suspension
    Ukai, M
    Maeda, H
    Hiramatsu, M
    Kameyama, T
    Matsuno, K
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (01) : R45 - R45
  • [7] Cardioprotective effect of selective sigma-1 receptor agonist SA4503 in transverse aortic constriction mice
    Hirano, Kohga
    Tagashira, Hideaki
    Fukunaga, Kohji
    ACTA PHARMACOLOGICA SINICA, 2013, 34 : 62 - 63
  • [8] Synthesis and evaluation of fluorine-18-labeled SA4503 as a selective sigma1 receptor ligand for positron emission tomography
    Kawamura, Kazunori
    Tsukada, Hideo
    Shiba, Kazuhiro
    Tsuji, Chieko
    Harada, Norihiro
    Kimura, Yuichi
    Ishlwata, Klichi
    NUCLEAR MEDICINE AND BIOLOGY, 2007, 34 (05) : 571 - 577
  • [9] Enhancement of acetylcholine release by SA4503, a novel sigma(1) receptor agonist, in the rat brain
    Kobayashi, T
    Matsuno, K
    Nakata, K
    Mita, S
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1996, 279 (01): : 106 - 113
  • [10] [11C]Raclopride binding was reduced in vivo by sigma1 receptor ligand SA4503 in the mouse brain, while [11C]SA4503 binding was not by raclopride
    Ishiwata, K
    Kobayashi, T
    Kawamura, K
    Matsuno, K
    Senda, M
    NUCLEAR MEDICINE AND BIOLOGY, 2001, 28 (07) : 787 - 792
1234