The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives

被引：16
|
作者：
Cheng, Elaine Y. [1 ,2 ]
机构：
[1] Terasaki Fdn Lab, Los Angeles, CA 90064 USA
[2] Univ Calif Los Angeles, Dept Surg, Div Liver & Pancreas Transplantat, Los Angeles, CA 90024 USA
来源：
JOURNAL OF IMMUNOLOGY RESEARCH | 2017年 / 2017卷
关键词：
ANTIBODY-MEDIATED REJECTION; HLA ANTIBODIES; LYMPHOCYTOTOXIC ALLOANTIBODIES; SENSITIZED RECIPIENTS; DIAGNOSIS; SURVIVAL; PLASMAPHERESIS; ABSORPTION; PATHOLOGY;
D O I：
10.1155/2017/3234906
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
More than ten years after the initial description of the humoral theory of transplantation by Dr. Paul I. Terasaki, the significance of humoral alloimmunity in liver transplantation has yet to be clearly defined. The liver allograft has an inherent tolerogenic capacity which confers its resistance to cell-mediated as well as antibody-mediated rejection. Nevertheless, the protection against alloimmunity is not complete, and antibody-mediated tissue injury can occur in the liver graft under specific circumstances. In this article the evidence on the clinicopathologic effects of donor-specific alloantibodies in liver transplantation will be examined and interpreted in parallel with lessons learned from renal transplantation. The unique anatomic and immunologic features of the liver will be reviewed to gain new insights into the complex interactions between humoral immune system and the liver allograft.
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页数：9
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