A practical approach to the synthesis of enantiomerically pure 2,6-disubstituted morpholines under phase transfer catalysis conditions

被引：9
|
作者：
Albanese, D. [1 ]
Foschi, F. [1 ]
Penso, M. [2 ]
机构：
[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
[2] Ist CNR ISTM, I-20133 Milan, Italy
来源：
CATALYSIS TODAY | 2009年 / 140卷 / 1-2期
关键词：
Phase transfer catalysis; Cyclization; Sulfonamides; Morpholines; ASYMMETRIC-SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; LIGANDS;
D O I：
10.1016/j.cattod.2008.07.005
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A novel, straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morpholines has been developed through the regioselective cyclization of diols. Cyclization precursors have been obtained by the ring opening of commercially available chiral epoxides under solid-liquid phase transfer catalysis conditions (SL-PTC). (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：100 / 104
页数：5
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