Toxoplasma gondii infection of human plasmacytoid dendritic cells inactivates TLR7 and-9 mediated induction of IFN-α and TNF-α in response to HIV and HSV

被引:0
|
作者
Pierog, Piotr [1 ]
Zhao, Yanlin [1 ]
Singh, Sukhwinder [1 ]
Yap, George [1 ]
Fitzgerald-Bocarsly, Patricia [1 ]
机构
[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA
来源
JOURNAL OF IMMUNOLOGY | 2011年 / 186卷
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
56.26
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
    Hornung, V
    Guenthner-Biller, M
    Bourquin, C
    Ablasser, A
    Schlee, M
    Uematsu, S
    Noronha, A
    Manoharan, M
    Akira, S
    de Fougerolles, A
    Endres, S
    Hartmann, G
    NATURE MEDICINE, 2005, 11 (03) : 263 - 270
  • [2] Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
    Veit Hornung
    Margit Guenthner-Biller
    Carole Bourquin
    Andrea Ablasser
    Martin Schlee
    Satoshi Uematsu
    Anne Noronha
    Muthiah Manoharan
    Shizuo Akira
    Antonin de Fougerolles
    Stefan Endres
    Gunther Hartmann
    Nature Medicine, 2005, 11 : 263 - 270
  • [3] Downregulation of TLR7/9 leads to deficient production of IFN-α from plasmacytoid dendritic cells in chronic hepatitis B
    Xu, Ning
    Yao, Hang-Ping
    Lv, Guo-Cai
    Chen, Zhi
    INFLAMMATION RESEARCH, 2012, 61 (09) : 997 - 1004
  • [4] Downregulation of TLR7/9 leads to deficient production of IFN-α from plasmacytoid dendritic cells in chronic hepatitis B
    Ning Xu
    Hang-Ping Yao
    Guo-Cai Lv
    Zhi Chen
    Inflammation Research, 2012, 61 : 997 - 1004
  • [5] The role of mTOR in TLR7/9 mediated signaling and cytokine production by human plasmacytoid dendritic cells
    Dai, Jihong
    Fitzgerald-Bocarsly, Patricia
    CYTOKINE, 2015, 76 (01) : 105 - 105
  • [6] HBsAg inhibits TLR9-mediated activation and IFN-α production in plasmacytoid dendritic cells
    Xu, Yongfen
    Hu, Yunwen
    Shi, Bisheng
    Zhang, Xiaonan
    Wang, Jiefei
    Zhang, Zhanqing
    Shen, Fang
    Zhang, Qin
    Sun, Shuhui
    Yuan, Zhenghong
    MOLECULAR IMMUNOLOGY, 2009, 46 (13) : 2640 - 2646
  • [7] Blocking TLR7-and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection
    Kader, Muhamuda
    Smith, Amanda P.
    Guiducci, Cristiana
    Wonderlich, Elizabeth R.
    Normolle, Daniel
    Watkins, Simon C.
    Barrat, Franck J.
    Barratt-Boyes, Simon M.
    PLOS PATHOGENS, 2013, 9 (07):
  • [8] TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN
    Di Domizio, Jeremy
    Blum, Ariane
    Gallagher-Gambarelli, Maighread
    Molens, Jean-Paul
    Chaperot, Laurence
    Plumas, Joel
    BLOOD, 2009, 114 (09) : 1794 - 1802
  • [9] CD300a/c regulate type I interferon and TNF-α secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands
    Ju, Xinsheng
    Zenke, Martin
    Hart, Derek N. J.
    Clark, Georgina J.
    BLOOD, 2008, 112 (04) : 1184 - 1194
  • [10] Signalling pathways leading to IFN-α production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications
    Guiducci, C.
    Coffman, R. L.
    Barrat, F. J.
    JOURNAL OF INTERNAL MEDICINE, 2009, 265 (01) : 43 - 57