Ion channels and transporters in lymphocyte function and immunity

被引：360

作者：

Feske, Stefan ^{[1
]}

Skolnik, Edward Y. ^{[2
,3
,4
]}

Prakriya, Murali ^{[5
]}

机构：

[1] NYU, Dept Pathol, Langone Med Ctr, New York, NY 10016 USA

[2] NYU, Helen L & Martin S Kimmel Ctr Biol & Med, Skirball Inst Biomol Med, Langone Med Ctr, New York, NY 10016 USA

[3] NYU, Div Nephrol, Dept Med, Langone Med Ctr, New York, NY 10016 USA

[4] NYU, Dept Pharmacol, Langone Med Ctr, New York, NY 10016 USA

[5] Northwestern Univ, Dept Mol Pharmacol & Biol Chem, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 07期

基金：

美国国家卫生研究院;

关键词：

T-CELL-ACTIVATION; OPERATED CA2+ ENTRY; TRANSMEMBRANE CONDUCTANCE REGULATOR; CA2+-ACTIVATED K+ CHANNEL; GATED POTASSIUM CHANNELS; CALCIUM SENSORS STIM1; MICE LACKING; CRAC CHANNELS; MITOCHONDRIAL CALCIUM; MOLECULAR CHARACTERIZATION;

D O I：

10.1038/nri3233

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphocyte function is regulated by a network of ion channels and transporters in the plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations of diverse cations, such as calcium, magnesium and zinc ions, which function as second messengers to regulate crucial lymphocyte effector functions, including cytokine production, differentiation and cytotoxicity. The repertoire of ion-conducting proteins includes calcium release-activated calcium (CRAC) channels, P2X receptors, transient receptor potential (TRP) channels, potassium channels, chloride channels and magnesium and zinc transporters. This Review discusses the roles of ion conduction pathways in lymphocyte function and immunity.

引用

页码：532 / 547

页数：16

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