Terminamines K-S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis

被引：8
|
作者：
Li, Xiang-Yu [1 ]
Yu, Yang [1 ]
Jia, Miao [1 ]
Jin, Mei-Na [1 ]
Qin, Nan [1 ]
Zhao, Chuan [1 ]
Duan, Hong-Quan [1 ]
机构：
[1] Tianjin Med Univ, Res Ctr Basic Med Sci, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China
来源：
MOLECULES | 2016年 / 21卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Pachysandra terminalis; Buxaceae; pregnane alkaloids; anti-metastatic activity; structure-activity relationships; CHEMOTAXIS;
D O I：
10.3390/molecules21101283
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nine newpregnane alkaloids (1-9), togetherwith eight known alkaloids (10-17), were isolated from the whole herb of Pachysandra terminalis. Their structures were elucidated on the basis of spectroscopic analyses. In addition, the isolates were examined for their ability to inhibit the migration of MDA-MB-231 cells induced by the chemokine epidermal growth factor (EGF). Alkaloids 1, 5, 7, 9, 12, and 17 presented significant anti-metastasis activities compared with the positive reagent, LY294002.
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页数：12
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