The 26S proteasome: A molecular machine designed for controlled proteolysis

被引:1522
|
作者
Voges, D [1 ]
Zwickl, P [1 ]
Baumeister, W [1 ]
机构
[1] Max Planck Inst Biochem, D-82152 Martinsried, Germany
关键词
protein degradation; ubiquitin; core complex; regulatory complex;
D O I
10.1146/annurev.biochem.68.1.1015
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built from similar to 31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins. The regulatory complexes are also implicated in unfolding and translocation of ubiquitinated targets into the interior of the 20S complex, where they are degraded to oligopeptides. Structure, assembly and enzymatic mechanism of the 20S complex have been elucidated, but the functional organization of the 19S complex is less well understood. Most subunits of the 19S complex have been identified, however, specific functions have been assigned to only a few. A low-resolution structure of the 26S proteasome has been obtained by electron microscopy, but the precise arrangement of subunits in the 19S complex is unclear.
引用
收藏
页码:1015 / 1068
页数:54
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