Dopamine in neurotoxicity and neuroprotection:: what do D2 receptors have to do with it?

被引：140
|
作者：
Bozzi, Y
Borrelli, E [1 ]
机构：
[1] ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Strasbourg, France
[2] CNR, Ist Neurosci, I-56100 Pisa, Italy
来源：
TRENDS IN NEUROSCIENCES | 2006年 / 29卷 / 03期
关键词：
D O I：
10.1016/j.tins.2006.01.002
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Accurate control of dopamine levels and/or the resulting dopamine-receptor interaction is essential for brain function. Indeed, several human neurological and psychiatric disorders are characterized by dysfunctions of the dopaminergic system. Dopamine has been reported to exert either protective or toxic effects on neurons, yet it is unclear whether these effects are receptor-dependent and, if so, which dopamine receptor could be involved. The D-2 dopamine receptor occupies a privileged position because its signalling might be neuroprotective in human diseases, such as Parkinson's disease, ischaemia and epilepsy. Unravelling the role of D-2 receptors in neuronal death and survival might be central to understanding the mechanisms that underlie several neuropathologies.
引用
收藏
页码：167 / 174
页数：8
相关论文
共 50 条
  • [41] Motoneurons do what motoneurons have to do
    Hounsgaard, J
    JOURNAL OF PHYSIOLOGY-LONDON, 2002, 538 (01): : 4 - 4
  • [42] WHAT MORE DO WE HAVE TO DO
    MEHIGAN, DJ
    BRITISH DENTAL JOURNAL, 1992, 173 (08) : 260 - 260
  • [43] Mechanisms of agonist action at D2 dopamine receptors
    Roberts, DJ
    Lin, H
    Strange, PG
    MOLECULAR PHARMACOLOGY, 2004, 66 (06) : 1573 - 1579
  • [44] A ROLE FOR DOPAMINE D2 RECEPTORS IN REVERSAL LEARNING
    Desteno, D. A.
    Schmauss, C.
    NEUROSCIENCE, 2009, 162 (01) : 118 - 127
  • [45] Cellular model of schizophrenic dopamine D2 receptors
    Lee, FJS
    Liu, F
    Wang, YT
    Pristupa, Z
    Niznik, HB
    SCHIZOPHRENIA RESEARCH, 1999, 36 (1-3) : 106 - 106
  • [46] Clozapine:: partial agonist at dopamine D2 receptors!
    Ninan, I
    Kulkarni, SK
    PSYCHOPHARMACOLOGY, 1998, 138 (02) : 215 - 216
  • [47] Clozapine: partial agonist at dopamine D2 receptors!
    I. Ninan
    S. K. Kulkarni
    Psychopharmacology, 1998, 138 : 215 - 216
  • [48] What do prisms have to do with forestry?
    Algonquin Provincial Park
    For. Chron., 2009, 2 (173):
  • [49] WHAT MORE DO WE HAVE TO DO
    GRACE, M
    BRITISH DENTAL JOURNAL, 1992, 173 (05) : 151 - 151
  • [50] What do networks have to do with climate?
    Tsonis, Anastasios A.
    Swanson, Kyle L.
    Roebber, Paul J.
    BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY, 2006, 87 (05) : 585 - +
12345