A novel effect of ethyl pyruvate in Schwann cell de-differentiation and proliferation during Wallerian degeneration

被引：4
|
作者：
Park, Byung Sun [1 ]
Jo, Hyun Woo [1 ]
Park, Chan [1 ]
Huh, Youngbuhm [1 ]
Jung, Junyang [1 ]
Jeong, Na Young [2 ]
机构：
[1] Kyung Hee Univ, Coll Med, Inst Biomed Sci, Dept Anat & Neurobiol, Seoul 130701, South Korea
[2] Dong A Univ, Dept Anat & Cell Biol, Coll Med, Busan 602714, South Korea
来源：
ANIMAL CELLS AND SYSTEMS | 2015年 / 19卷 / 04期
关键词：
Schwann cell de-differentiation; Wallerian degeneration; sciatic explant; Schwann cell proliferation; Ethyl pyruvate; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; PERIPHERAL-NERVE; NEURONAL DEATH; INJURY; REGENERATION; MYELINATION; EXPRESSION; PROTECTION; APOPTOSIS;
D O I：
10.1080/19768354.2015.1053520
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ethyl pyruvate (EP), as a pyruvate derivative, has the protective effect on oxidative-stress-mediated cellular injury. In previous studies, it has been reported that EP provides protection against neuronal injury in brain, for example transient cerebral ischemia. However, the inhibition effect of EP on peripheral nerve injury is still unknown. Here, we investigated the inhibition effect of EP in Schwann cell de-differentiation and proliferation during Wallerian degeneration using ex vivo sciatic nerve explant system. We demonstrated that EP inhibits p-ERK1/2, p75NGFR, and lysosomal associated membrane protein 1 as factors implicated in Schwann cell de-differentiation during Wallerian degeneration. In addition, EP is sufficient to inhibit Schwann cell proliferation during Wallerian degeneration. Together, these findings suggest that EP has a strong protective effect on Wallerain degeneration.
引用
收藏
页码：262 / 268
页数：7
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