A novel effect of ethyl pyruvate in Schwann cell de-differentiation and proliferation during Wallerian degeneration

被引：4

作者：

Park, Byung Sun ^{[1
]}

Jo, Hyun Woo ^{[1
]}

Park, Chan ^{[1
]}

Huh, Youngbuhm ^{[1
]}

Jung, Junyang ^{[1
]}

Jeong, Na Young ^{[2
]}

机构：

[1] Kyung Hee Univ, Coll Med, Inst Biomed Sci, Dept Anat & Neurobiol, Seoul 130701, South Korea

[2] Dong A Univ, Dept Anat & Cell Biol, Coll Med, Busan 602714, South Korea

来源：

ANIMAL CELLS AND SYSTEMS | 2015年 / 19卷 / 04期

关键词：

Schwann cell de-differentiation; Wallerian degeneration; sciatic explant; Schwann cell proliferation; Ethyl pyruvate; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; PERIPHERAL-NERVE; NEURONAL DEATH; INJURY; REGENERATION; MYELINATION; EXPRESSION; PROTECTION; APOPTOSIS;

D O I：

10.1080/19768354.2015.1053520

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ethyl pyruvate (EP), as a pyruvate derivative, has the protective effect on oxidative-stress-mediated cellular injury. In previous studies, it has been reported that EP provides protection against neuronal injury in brain, for example transient cerebral ischemia. However, the inhibition effect of EP on peripheral nerve injury is still unknown. Here, we investigated the inhibition effect of EP in Schwann cell de-differentiation and proliferation during Wallerian degeneration using ex vivo sciatic nerve explant system. We demonstrated that EP inhibits p-ERK1/2, p75NGFR, and lysosomal associated membrane protein 1 as factors implicated in Schwann cell de-differentiation during Wallerian degeneration. In addition, EP is sufficient to inhibit Schwann cell proliferation during Wallerian degeneration. Together, these findings suggest that EP has a strong protective effect on Wallerain degeneration.

引用

页码：262 / 268

页数：7

共 50 条

[1] Effect of liposome-mediated macrophage depletion on Schwann cell proliferation during Wallerian degeneration
Kubota, A
Suzuki, K
JOURNAL OF NEUROTRAUMA, 2000, 17 (09) : 789 - 798
[2] Effect of macrophage suppression with silica on the proliferation of Schwann cells during Wallerian degeneration
Kubota, A
Komiyama, A
Matsumoto, M
Suzuki, K
BRAIN RESEARCH, 1998, 802 (1-2) : 254 - 258
[3] HoloTransferrin but not ApoTransferrin prevents Schwann cell de-differentiation in culture
Salis, C
Goedelmann, CJ
Pasquini, JM
Soto, EF
Setton-Avruj, CP
DEVELOPMENTAL NEUROSCIENCE, 2002, 24 (2-3) : 214 - 221
[4] Interleukin-1β Promotes Schwann Cells De-Differentiation in Wallerian Degeneration via the c-JUN/AP-1 Pathway
Chen, Gang
Luo, Xiaohe
Wang, Wenjin
Wang, Yimei
Zhu, Fei
Wang, Wei
FRONTIERS IN CELLULAR NEUROSCIENCE, 2019, 13
[5] The neuregulins in Wallerian degeneration: A potential molecular trigger for Schwann cell proliferation.
Carroll, SL
Miller, ML
Frohnert, PW
Kim, SS
Corbett, JA
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1996, 55 (05): : 105 - 105
[6] MACROPHAGE-LIKE CHARACTERISTICS OF SCHWANN CELL DURING WALLERIAN DEGENERATION
NUSSER, WL
ANATOMICAL RECORD, 1964, 148 (02): : 419 - &
[7] NORMAL RATE OF SCHWANN-CELL PROLIFERATION IN THE MBP-DEFICIENT SHIVERER MOUSE DURING WALLERIAN DEGENERATION
KOMIYAMA, A
SUZUKI, K
BRAIN RESEARCH, 1991, 563 (1-2) : 345 - 348
[8] RELATION BETWEEN K+ CHANNEL EXPRESSION AND SCHWANN-CELL PROLIFERATION IN WALLERIAN DEGENERATION
CHIU, SY
WILSON, G
BIOPHYSICAL JOURNAL, 1988, 53 (02) : A458 - A458
[9] Extracellular ATP inhibits Schwann cell dedifferentiation and proliferation in an ex vivo model of Wallerian degeneration
Shin, Youn Ho
Lee, Seo Jin
Jung, Junyang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 430 (02) : 852 - 857
[10] STUDIES OF SCHWANN-CELL PROLIFERATION .1. ANALYSIS IN TISSUE-CULTURE OF PROLIFERATION DURING DEVELOPMENT, WALLERIAN DEGENERATION, AND DIRECT INJURY
SALZER, JL
BUNGE, RP
JOURNAL OF CELL BIOLOGY, 1980, 84 (03): : 739 - 752

← 1 2 3 4 5 →